GRINA and TIAL1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GRINA	TIAL1
Name		glutamate ionotropic receptor NMDA type subunit associated protein 1	TIA1 cytotoxic granule associated RNA binding protein like 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Cytolytic Granule
	Molecular Function	Calcium Channel Activity Protein Binding Transmembrane Transporter Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Protein-RNA Adaptor Activity
	Biological Process	Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		None	FGFR2 alternative splicing
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Fibrinogen levels ( 28107422 ) LDL cholesterol ( 25961943 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 )	Depressive symptoms (stressful life events interaction) ( 27529621 ) Monocyte percentage of white cells ( 32888494 ) Parkinson's disease ( 27182965 ) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539 )
Interacting Genes		9 interacting genes: DRD2 FMO1 GGT6 GLP1R GPX8 KRTAP19-5 KRTAP6-2 TIAL1 TMEM242	42 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CEBPA CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRT31 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C
Entrez ID		2907	7073
HPRD ID		15927	04563
Ensembl ID		ENSG00000178719	ENSG00000151923
Uniprot IDs		Q7Z429	Q01085 Q49AS9
PDB IDs		Not available	1X4G 2CQI 2DH7
GO Terms Enriched among Interactors		None	MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Extracellular Vesicle Post-transcriptional Regulation Of Gene Expression Regulation Of Angiogenesis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of BMP Signaling Pathway RNA Splicing Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction MRNA Destabilization Regulation Of MRNA Stability RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration