GRINA and FMO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRINA	FMO1
Description		glutamate ionotropic receptor NMDA type subunit associated protein 1	flavin containing dimethylaniline monoxygenase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Transmembrane Transporter Binding	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Sulfur Amino Acid Catabolic Process Organic Acid Metabolic Process Xenobiotic Metabolic Process Toxin Metabolic Process Response To Lipopolysaccharide Taurine Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Energy Homeostasis
Pathways			Degradation of cysteine and homocysteine FMO oxidises nucleophiles
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 28107422) LDL cholesterol ( 25961943) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)	Metabolite levels ( 23823483) Sudden cardiac arrest ( 21658281) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		9 interacting genes: DRD2 FMO1 GGT6 GLP1R GPX8 KRTAP19-5 KRTAP6-2 TIAL1 TMEM242	7 interacting genes: CREB3 GRINA LEPROTL1 REEP4 SLC10A6 SLC71A2 TLN1
Entrez ID		2907	2326
HPRD ID		15927	00631
Ensembl ID		ENSG00000178719	ENSG00000010932
Uniprot IDs		Q7Z429	B2RCG5 Q01740
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
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