GRIK3 and PICK1

Number of citations of the paper that reports this interaction (PMID 11891216)
25

Data Source:
BioGRID (two hybrid, pull down)

		GRIK3	PICK1
Gene Name		glutamate receptor, ionotropic, kainate 3	protein interacting with PRKCA 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density
	Molecular Function	Adenylate Cyclase Inhibiting G-protein Coupled Glutamate Receptor Activity Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity Kainate Selective Glutamate Receptor Activity	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Presynaptic function of Kainate receptors Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Schizophrenia ( 23894747)
Protein-Protein Interactions		5 interactors: FLNA GRIK5 GRIP1 PICK1 SDCBP	47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7
Entrez ID		2899	9463
HPRD ID		00691	16176
Ensembl ID		ENSG00000163873	ENSG00000100151
Uniprot IDs		A9Z1Z8 Q13003	B3KS52 Q9NRD5
PDB IDs			2GZV
Enriched GO Terms of Interacting Partners?		Receptor Clustering Protein Localization To Membrane Synaptic Transmission Protein Localization Membrane Organization Cell-cell Signaling Cell Projection Organization Regulation Of Vesicle-mediated Transport Cellular Protein Localization Cell Development Establishment Of Localization In Cell Positive Regulation Of Transport Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Exocytosis Cellular Localization Regulation Of Organelle Organization Signal Transduction Neuron Development Regulation Of Cellular Localization Signaling Positive Regulation Of Extracellular Vesicular Exosome Assembly Cell Communication Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron Differentiation Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cell Projection Assembly DNA Methylation Involved In Embryo Development Regulation Of Synaptic Transmission Cellular Response To Stimulus Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendritic Spine Maintenance Protein Retention In ER Lumen Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Maintenance Of Protein Localization In Endoplasmic Reticulum Intracellular Transport MRNA Transcription From RNA Polymerase II Promoter Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Generation Of Neurons Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation MRNA Transcription Protein Targeting	Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death
Tagcloud ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Difference) ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Intersection) ?