GRIK3 and GRIP1

Number of citations of the paper that reports this interaction (PMID 11891216)
25

Data Source:
BioGRID (two hybrid, pull down)

		GRIK3	GRIP1
Gene Name		glutamate receptor, ionotropic, kainate 3	glutamate receptor interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Dendrite Neuron Projection Membrane Raft Postsynaptic Membrane Recycling Endosome
	Molecular Function	Adenylate Cyclase Inhibiting G-protein Coupled Glutamate Receptor Activity Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity Kainate Selective Glutamate Receptor Activity	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Receptor Signaling Complex Scaffold Activity Glucocorticoid Receptor Binding Androgen Receptor Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic	Synaptic Transmission Protein Localization Dendrite Development Androgen Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated
Pathways		Presynaptic function of Kainate receptors Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Schizophrenia ( 23894747)
Protein-Protein Interactions		5 interactors: FLNA GRIK5 GRIP1 PICK1 SDCBP	34 interactors: AR CARM1 CSPG4 EFNA5 EFNB1 EFNB2 EP300 ESR1 FLII GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIPAP1 GRM3 HIST1H3A IRF3 NCOA6 NR2F1 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA RXRB THRA UBE2I VDR
Entrez ID		2899	23426
HPRD ID		00691	19086
Ensembl ID		ENSG00000163873	ENSG00000155974
Uniprot IDs		A9Z1Z8 Q13003	Q9Y3R0
PDB IDs			2JIL
Enriched GO Terms of Interacting Partners?		Receptor Clustering Protein Localization To Membrane Synaptic Transmission Protein Localization Membrane Organization Cell-cell Signaling Cell Projection Organization Regulation Of Vesicle-mediated Transport Cellular Protein Localization Cell Development Establishment Of Localization In Cell Positive Regulation Of Transport Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Exocytosis Cellular Localization Regulation Of Organelle Organization Signal Transduction Neuron Development Regulation Of Cellular Localization Signaling Positive Regulation Of Extracellular Vesicular Exosome Assembly Cell Communication Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron Differentiation Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cell Projection Assembly DNA Methylation Involved In Embryo Development Regulation Of Synaptic Transmission Cellular Response To Stimulus Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendritic Spine Maintenance Protein Retention In ER Lumen Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Maintenance Of Protein Localization In Endoplasmic Reticulum Intracellular Transport MRNA Transcription From RNA Polymerase II Promoter Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Generation Of Neurons Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation MRNA Transcription Protein Targeting	Intracellular Receptor Signaling Pathway Signal Transduction Glutamate Receptor Signaling Pathway Signaling Cell Communication Steroid Hormone Mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Synaptic Transmission, Glutamatergic Cellular Response To Stimulus DNA-templated Transcription, Initiation Cellular Response To Steroid Hormone Stimulus Neuron-neuron Synaptic Transmission Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Response To Organic Cyclic Compound Cell-cell Signaling Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter System Development Response To Lipid Multicellular Organismal Development Transcription From RNA Polymerase II Promoter Negative Regulation Of Synaptic Transmission Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Cellular Response To Organic Substance Synaptic Transmission Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Developmental Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process
Tagcloud ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src
Tagcloud (Difference) ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	acids androgen associate auxiliary beta1 box cip coactivator coactivators efficient equivalent glucocorticoid hormone includes lacks lxxll motifs mutational nid nidaux nr nrs p160 progesterone recruit retinoid separable src
Tagcloud (Intersection) ?