GRIK3 and SDCBP

Number of citations of the paper that reports this interaction (PMID 11891216)
25

Data Source:
BioGRID (pull down)

		GRIK3	SDCBP
Gene Name		glutamate receptor, ionotropic, kainate 3	syndecan binding protein (syntenin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Vesicle Melanosome Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Adenylate Cyclase Inhibiting G-protein Coupled Glutamate Receptor Activity Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity Kainate Selective Glutamate Receptor Activity	Glycoprotein Binding Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Protein C-terminus Binding Cytoskeletal Adaptor Activity Growth Factor Binding Neurexin Family Protein Binding Identical Protein Binding Protein Homodimerization Activity Syndecan Binding Ephrin Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding Cell Adhesion Molecule Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic	Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Presynaptic function of Kainate receptors Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Ephrin signaling Axon guidance Neurofascin interactions EPH-Ephrin signaling L1CAM interactions
Drugs		L-Glutamic Acid
Diseases
GWAS		Schizophrenia ( 23894747)
Protein-Protein Interactions		5 interactors: FLNA GRIK5 GRIP1 PICK1 SDCBP	167 interactors: ABI2 AES ANKRD40 ANP32B APIP BCL2L15 C11orf57 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CCDC102B CCDC36 CCDC53 CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DAK DCTD DCTPP1 DMC1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRM3 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NOTCH2NL NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTPRJ PTS PUF60 PYCRL RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SDCCAG3 SEPT3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBE2A ULK1 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17
Entrez ID		2899	6386
HPRD ID		00691	03741
Ensembl ID		ENSG00000163873	ENSG00000137575
Uniprot IDs		A9Z1Z8 Q13003	B4DHN5 G5EA09 O00560
PDB IDs			1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO
Enriched GO Terms of Interacting Partners?		Receptor Clustering Protein Localization To Membrane Synaptic Transmission Protein Localization Membrane Organization Cell-cell Signaling Cell Projection Organization Regulation Of Vesicle-mediated Transport Cellular Protein Localization Cell Development Establishment Of Localization In Cell Positive Regulation Of Transport Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Exocytosis Cellular Localization Regulation Of Organelle Organization Signal Transduction Neuron Development Regulation Of Cellular Localization Signaling Positive Regulation Of Extracellular Vesicular Exosome Assembly Cell Communication Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron Differentiation Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cell Projection Assembly DNA Methylation Involved In Embryo Development Regulation Of Synaptic Transmission Cellular Response To Stimulus Cell Differentiation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dendritic Spine Maintenance Protein Retention In ER Lumen Establishment Of Protein Localization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Maintenance Of Protein Localization In Endoplasmic Reticulum Intracellular Transport MRNA Transcription From RNA Polymerase II Promoter Neuronal Ion Channel Clustering Substrate-dependent Cell Migration, Cell Extension Generation Of Neurons Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Actin Nucleation MRNA Transcription Protein Targeting	Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Neuron-neuron Synaptic Transmission Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Synaptic Transmission Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Homooligomerization Positive Regulation Of Exocytosis Protein Tetramerization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Metabolic Process Regulation Of Cellular Component Organization Protein Oligomerization Protein Homotetramerization Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Stimulus Cell-cell Signaling Regulation Of Synaptic Transmission Cellular Process Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Viral Release From Host Cell Gene Expression Positive Regulation Of Secretion Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process RNA Splicing Protein Modification By Small Protein Conjugation Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Ephrin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Nucleoside Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Negative Regulation Of Synaptic Transmission RNA Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Protein Polyubiquitination
Tagcloud ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound
Tagcloud (Difference) ?		appearance comprehending correlate epigenetic epigenetics etc foxg1 hand2 hox integrating islands luad methylated neurog1 nkx6 pik3ca pik3r3 pou4f2 prkcb ptgdr raf1 rap1a refers stages subnetwork tlx3 ubc ultimate wise	conversely datasets fak healing hepatocyte hgf il2rgamma immunofluorescence indication lethality matrigel mda melanoma melanomas metastases metastasizes metastatic migrate opposite pseudo scid syndecan syndecans syntenin triggered unrelated uveal warrants wound
Tagcloud (Intersection) ?