NTMT1 and DDB2

Number of citations of the paper that reports this interaction (PMID 24753253)
0

Data Source:
BioGRID (enzymatic study)

		NTMT1	DDB2
Gene Name		N-terminal Xaa-Pro-Lys N-methyltransferase 1	damage-specific DNA binding protein 2, 48kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Cell Junction Cul4B-RING E3 Ubiquitin Ligase Complex Protein Complex
	Molecular Function	Protein Methyltransferase Activity	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Spindle Organization Chromosome Segregation N-terminal Peptidyl-alanine Trimethylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation	Protein Polyubiquitination Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Response To UV Histone H2A Monoubiquitination Protein Autoubiquitination UV-damage Excision Repair
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP DDB2 DIS3 HNRNPD IKBKG RCC1	15 interactors: ABL1 CUL4A CUL4B DCLRE1C DDB1 E2F1 HDAC1 HIST2H2AC HIST2H3C NTMT1 TOP1 USP24 USP40 XPA XPC
Entrez ID		28989	1643
HPRD ID		10628	02886
Ensembl ID		ENSG00000148335	ENSG00000134574
Uniprot IDs		Q9BV86 S4R338	Q92466
PDB IDs		2EX4	3EI4 3I7L 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Aromatic Compound Catabolic Process MRNA Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cellular Macromolecule Catabolic Process RNA Catabolic Process CUT Catabolic Process Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Translation Positive Regulation Of Hydrolase Activity Axon Choice Point Recognition UV-damage Excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Positive Regulation Of Ran GTPase Activity Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Positive Regulation Of Protein Metabolic Process Response To Light Stimulus RRNA Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Pyrimidine Dimer Repair Histone H2A Ubiquitination RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Positive Regulation Of Gene Expression Nucleotide-excision Repair, DNA Damage Removal Cellular Copper Ion Homeostasis Response To Radiation Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Histone Monoubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior	DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process DNA Repair Regulation Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Catabolic Process Regulation Of Cell Cycle Cellular Response To Stress Response To UV DNA Catabolic Process Intrinsic Apoptotic Signaling Pathway Response To Radiation Response To Stress UV-damage Excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Histone H2A Monoubiquitination Nucleotide-excision Repair Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Abiotic Stimulus Histone H2A Ubiquitination Response To Light Stimulus Positive Regulation Of Mitotic Cell Cycle Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Cellular Metabolic Process Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone Monoubiquitination Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Aromatic Compound Catabolic Process Negative Regulation Of Cell Cycle Interaction With Symbiont
Tagcloud ?			adherens bioassays bladder carcinogenic carcinogens chemicals consistently construct discriminate evaluating foundation gadd45a genotoxic genotoxicity globaltest hepg2 implemented industry investigating junction microarrays pam peroxisome perturbation pharmaceutical rrm2b set sets validate
Tagcloud (Difference) ?			adherens bioassays bladder carcinogenic carcinogens chemicals consistently construct discriminate evaluating foundation gadd45a genotoxic genotoxicity globaltest hepg2 implemented industry investigating junction microarrays pam peroxisome perturbation pharmaceutical rrm2b set sets validate
Tagcloud (Intersection) ?