NTMT1 and DIS3

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		NTMT1	DIS3
Gene Name		N-terminal Xaa-Pro-Lys N-methyltransferase 1	DIS3 exosome endoribonuclease and 3-5 exoribonuclease
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	Protein Methyltransferase Activity	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Spindle Organization Chromosome Segregation N-terminal Peptidyl-alanine Trimethylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression RRNA Catabolic Process Positive Regulation Of GTPase Activity Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP DDB2 DIS3 HNRNPD IKBKG RCC1	12 interactors: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MPP6 NTMT1 SKIV2L2 ZBTB17
Entrez ID		28989	22894
HPRD ID		10628	06338
Ensembl ID		ENSG00000148335	ENSG00000083520
Uniprot IDs		Q9BV86 S4R338	G3V1J5 Q9Y2L1
PDB IDs		2EX4
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Aromatic Compound Catabolic Process MRNA Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cellular Macromolecule Catabolic Process RNA Catabolic Process CUT Catabolic Process Intracellular Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Translation Positive Regulation Of Hydrolase Activity Axon Choice Point Recognition UV-damage Excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Positive Regulation Of Ran GTPase Activity Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Positive Regulation Of Protein Metabolic Process Response To Light Stimulus RRNA Catabolic Process Histone H2A Monoubiquitination Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Pyrimidine Dimer Repair Histone H2A Ubiquitination RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Positive Regulation Of Gene Expression Nucleotide-excision Repair, DNA Damage Removal Cellular Copper Ion Homeostasis Response To Radiation Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Histone Monoubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Copper Ion Homeostasis Suckling Behavior	RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Catabolic Process Maturation Of 5.8S RRNA MRNA Metabolic Process Nuclear MRNA Surveillance RNA Surveillance RNA Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis DNA Deamination RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process CUT Catabolic Process Histone MRNA Catabolic Process DNA Modification Intracellular MRNA Localization Positive Regulation Of Cell Growth Cellular Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Growth N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-alanine Trimethylation Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-serine Trimethylation Regulation Of Cell Growth Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Metabolic Process
Tagcloud ?			braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Difference) ?			braf copy decisions deletions determining discovered emphasize fam46c heterogeneity heterozygosity homozygous kras massively modeling mutated myeloma nonhyperdiploid nonmutated nras paired parallel partial particularly predicts promotion putative subclonal subclones tp53
Tagcloud (Intersection) ?