CCNQ and PTPN5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CCNQ	PTPN5
Name		cyclin Q	protein tyrosine phosphatase non-receptor type 5
Structure		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cell Junction
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle G2/M Phase Transition	Protein Dephosphorylation Signal Transduction
Pathways		None	Interleukin-37 signaling
GWAS		No GWAS studies recorded	Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065 ) Myopia ( 27182965 ) Refractive error ( 32231278 )
Interacting Genes		2 interacting genes: GPR37 PTPN5	19 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FYN MAPK1 MAPK3 MARCHF5 MOB1A PRKN SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5
Entrez ID		92002	84867
HPRD ID		06645	01472
Ensembl ID		ENSG00000262919	ENSG00000110786
Uniprot IDs		Q8N1B3	B7Z2F8 P54829 Q86TL3
PDB IDs		Not available	2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R 8SLS 8SLT 8SLU 9EEX 9EEY 9EEZ
GO Terms Enriched among Interactors		Prosaposin Receptor Activity Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Regulation Of Dopamine Metabolic Process Amine Biosynthetic Process Neuropeptide Binding Endoplasmic Reticulum Membrane Catecholamine Biosynthetic Process Peptide Binding Biogenic Amine Biosynthetic Process Neuropeptide Receptor Activity Dopamine Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development Catecholamine Metabolic Process Hsp70 Protein Binding Phosphotyrosine Residue Binding Endoplasmic Reticulum Biogenic Amine Metabolic Process Heat Shock Protein Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Amine Metabolic Process PDZ Domain Binding Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Neuropeptide Signaling Pathway Ubiquitin Ligase Complex Cellular Response To Reactive Oxygen Species Dephosphorylation Phosphoprotein Phosphatase Activity	Positive Regulation Of Cellular Component Organization Positive Regulation Of Defense Response ERBB2 Signaling Pathway Interleukin-34-mediated Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Organelle Organization Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Defense Response Negative Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamate Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Inflammatory Response Immune Response-activating Signaling Pathway Bergmann Glial Cell Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Immune Response ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Protein K27-linked Ubiquitination Regulation Of Golgi Organization MAP Kinase Activity Pseudopodium Organelle Localization Layer Formation In Cerebral Cortex Response To L-glutamate Positive Regulation Of Macroautophagy Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Phospholipase Binding Positive Regulation Of Mitochondrial Fission Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Chromosome Organization Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Protein K48-linked Ubiquitination Face Development Regulation Of Telomere Maintenance