LSMEM1 and CD53

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSMEM1	CD53
Description		leucine rich single-pass membrane protein 1	CD53 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction Membrane Specific Granule Membrane Synapse Extracellular Exosome Anchoring Junction Tertiary Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein-membrane Adaptor Activity
	Biological Process		Signal Transduction Receptor Clustering T Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)
Interacting Genes		6 interacting genes: APP CD53 LSMEM2 MAL TMEM80 ZDHHC15	80 interacting genes: AIG1 APOD ARL13B ASGR2 ATP6V0C BCL2L13 BIK BTN2A2 C1QL4 CD2 CD302 CD37 CD4 CD9 CLCN7 CLDN19 CLDN7 CLEC7A CNIH1 CNIH2 COL4A5 CREB3L1 CTXN3 CXCL16 CYBC1 ECE2 EFNA5 EMP1 ERG28 FAM209A GET1 GGT1 GIMAP5 GJA8 GPR108 GPR152 GPX8 IFITM3 IGFBP5 IL2 IL4 KIR3DL3 LAT LHFPL5 LPAR3 LSMEM1 MAL MS4A3 MUC1 NKG7 PLN PLP2 PMP22 PSCA RPRM SAR1A SERTM1 SLC35A1 SLC7A14 SMAGP SMIM3 SNORC ST6GAL2 STRIT1 STX2 TMEM128 TMEM140 TMEM218 TMEM229B TMEM237 TMEM60 TMEM86B TMEM97 TRAM1L1 TRARG1 TSPO2 UBIAD1 UPK1B VAMP5 VSTM1
Entrez ID		286006	963
HPRD ID		08258	01054
Ensembl ID		ENSG00000181016	ENSG00000143119
Uniprot IDs		Q8N8F7	B4DQB5 P19397
PDB IDs			6WVG
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Postsynapse Organization Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Localization Within Membrane Protein Insertion Into Plasma Membrane Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Targeting To Golgi Apparatus Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Developmental Maturation NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Establishment Of Protein Localization To Membrane Protein-cysteine S-stearoyltransferase Activity Membrane Raft Axon Choice Point Recognition	Membrane Plasma Membrane Membrane Raft Distribution Membrane Raft Localization Protein Binding Bleb Assembly Membrane Raft Polarization T Cell Activation Endomembrane System Membrane Raft Organization Endoplasmic Reticulum Membrane Defense Response To Protozoan Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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