LSMEM1 and ZDHHC15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSMEM1	ZDHHC15
Description		leucine rich single-pass membrane protein 1	zDHHC palmitoyltransferase 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Postsynaptic Density Membrane Synapse Postsynapse
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Metal Ion Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process		Protein Targeting To Membrane Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Establishment Of Protein Localization Regulation Of Dendritic Spine Morphogenesis Protein Localization To Postsynapse Protein Localization To Membrane Protein Targeting To Golgi Apparatus Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		6 interacting genes: APP CD53 LSMEM2 MAL TMEM80 ZDHHC15	49 interacting genes: ADCYAP1R1 ARL13B BNIP3 C14orf180 CD79A CELA2B CERCAM CFTR CLEC10A CLRN1 CREB3L1 CYB5R3 DHRSX ERGIC3 FAM241B GIMAP1 GOLGA7B GPR152 LEMD1 LEPROTL1 LHFPL5 LMNA LSMEM1 MCEMP1 MTIF3 ORMDL1 ORMDL2 PEX16 PLLP PRAF2 PVR RUSF1 SLC10A6 SMIM1 SNORC STX3 TBXA2R TMEFF2 TMEM120B TMEM128 TMEM14C TMEM222 TMEM42 TMEM52B TNFRSF10B TSNARE1 TUFM VAPB YIPF4
Entrez ID		286006	158866
HPRD ID		08258	06758
Ensembl ID		ENSG00000181016	ENSG00000102383
Uniprot IDs		Q8N8F7	B3KY34 Q96MV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Postsynapse Organization Cellular Localization Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Localization Within Membrane Protein Insertion Into Plasma Membrane Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Targeting To Golgi Apparatus Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Developmental Maturation NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Establishment Of Protein Localization To Membrane Protein-cysteine S-stearoyltransferase Activity Membrane Raft Axon Choice Point Recognition	Membrane Membrane Docking Organelle Localization By Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Protein Binding Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex
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