OBSCN

Gene Name		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
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Gene Ontology Annotations	Cellular Component	Cytosol Myofibril Z Disc M Band
	Molecular Function	Protein Serine/threonine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Ankyrin Binding Titin Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Small GTPase Mediated Signal Transduction Multicellular Organismal Development Positive Regulation Of Rho GTPase Activity Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: ANK1 ANK2 BRCA1 CALM1 MYH2 TTN
Entrez ID		84033
HPRD ID		10551
Ensembl ID		ENSG00000154358
Uniprot IDs		H3BPX2 Q5VST9
PDB IDs		1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2YZ8
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Plasma Membrane Organization Membrane Organization Actin-myosin Filament Sliding Muscle Filament Sliding Positive Regulation Of Cation Channel Activity Protein Targeting To Plasma Membrane Actin-mediated Cell Contraction Exocytosis Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Contraction Positive Regulation Of Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Actin Filament-based Movement Heart Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Endomembrane System Organization Platelet Degranulation Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Transport Into Cytosol Striated Muscle Contraction Secretion By Cell Vesicle-mediated Transport Regulation Of Striated Muscle Contraction Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Calcium-mediated Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Localization To T-tubule Wound Healing Response To Calcium Ion Secretion Response To External Stimulus Response To Wounding Positive Regulation Of Histone H3-K9 Acetylation T-tubule Organization Protein Localization To M-band Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity
Tagcloud ?		0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1