OBSCN

Description		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Myofibril Z Disc M Band Sarcolemma
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Kinase Activity Transferase Activity Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Cell Differentiation Protein Localization To M-band Sarcomere Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)
Interacting Genes		8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN
Entrez ID		84033
HPRD ID		10551
Ensembl ID		ENSG00000154358
Uniprot IDs		A6NGQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		M Band Transmembrane Transporter Binding Enzyme Binding Z Disc A Band Actin-myosin Filament Sliding Muscle Filament Sliding Cytoskeletal Anchor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Spectrin Binding Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Actin-mediated Cell Contraction Condensed Nuclear Chromosome Protein-containing Complex Sarcomere Regulation Of Action Potential Actin Filament-based Movement Protein Localization To T-tubule Structural Constituent Of Cytoskeleton ATPase Binding Protein Kinase Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Localization To M-band Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Atrial Cardiac Muscle Cell To AV Node Cell Communication Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Regulation Of Heart Rate Sarcolemma Skeletal Muscle Myosin Thick Filament Assembly Regulation Of Sequestering Of Calcium Ion Maintenance Of Epithelial Cell Apical/basal Polarity Structural Molecule Activity Ankyrin-1 Complex Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Atrial Cardiac Muscle Cell Action Potential Potassium Channel Activator Activity Calcium-mediated Signaling SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication
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