OBSCN and MYH2

Number of citations of the paper that reports this interaction (PMID 15013951)
22

Data Source:
HPRD (in vivo)

		OBSCN	MYH2
Gene Name		obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	myosin, heavy chain 2, skeletal muscle, adult
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Myofibril Z Disc M Band	Golgi Apparatus Actomyosin Contractile Ring Cytosol Muscle Myosin Complex Cell-cell Junction Myofibril Sarcomere A Band Myosin Filament Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Ankyrin Binding Titin Binding Metal Ion Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Protein Phosphorylation Small GTPase Mediated Signal Transduction Multicellular Organismal Development Positive Regulation Of Rho GTPase Activity Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Plasma Membrane Repair Muscle Contraction Metabolic Process Response To Activity Muscle Filament Sliding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Membrane Organization
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Translocation of GLUT4 to the plasma membrane Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ANK1 ANK2 BRCA1 CALM1 MYH2 TTN	6 interactors: AMPD1 DGKD OBSCN PRKCE PTK2B S100A4
Entrez ID		84033	4620
HPRD ID		10551	01173
Ensembl ID		ENSG00000154358	ENSG00000125414
Uniprot IDs		H3BPX2 Q5VST9	Q567P6 Q9UKX2
PDB IDs		1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2YZ8
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Plasma Membrane Organization Membrane Organization Actin-myosin Filament Sliding Muscle Filament Sliding Positive Regulation Of Cation Channel Activity Protein Targeting To Plasma Membrane Actin-mediated Cell Contraction Exocytosis Positive Regulation Of Ion Transmembrane Transporter Activity Cardiac Muscle Contraction Positive Regulation Of Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Actin Filament-based Movement Heart Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Endomembrane System Organization Platelet Degranulation Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Regulation Of Calcium Ion Transport Into Cytosol Striated Muscle Contraction Secretion By Cell Vesicle-mediated Transport Regulation Of Striated Muscle Contraction Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Calcium-mediated Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Protein Localization To T-tubule Wound Healing Response To Calcium Ion Secretion Response To External Stimulus Response To Wounding Positive Regulation Of Histone H3-K9 Acetylation T-tubule Organization Protein Localization To M-band Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Epithelial Cell Migration Response To Ammonium Ion Negative Regulation Of Ion Transport Positive Regulation Of Cellular Glucuronidation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Transmission Actomyosin Structure Organization Regulation Of Receptor Activity Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Protein Polymerization Regulation Of Intracellular Signal Transduction Cell Activation Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis TRAM-dependent Toll-like Receptor 4 Signaling Pathway Phosphorylation Response To Ethanol Intracellular Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration Response To Alkaloid Regulation Of Transmembrane Transporter Activity Regulation Of Carbohydrate Metabolic Process Leukocyte Activation Involved In Immune Response Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Protein Localization To M-band Positive Regulation Of Protein Complex Assembly Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Actin Filament Polymerization Cytosolic Calcium Ion Homeostasis Activation Of Janus Kinase Activity Platelet Activation Regulation Of Cell-substrate Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1	breakpoint breaks coliai cryb1 d17s1 d17s19 d17s6 d17z erba1 gaa galk gcsf ghc hox2 hybrids isoenzymes mpo myh1 ngfr ngl probes pter qter regionally rnp2 rnu2 tk1 transfectant um
Tagcloud (Difference) ?		0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1	breakpoint breaks coliai cryb1 d17s1 d17s19 d17s6 d17z erba1 gaa galk gcsf ghc hox2 hybrids isoenzymes mpo myh1 ngfr ngl probes pter qter regionally rnp2 rnu2 tk1 transfectant um
Tagcloud (Intersection) ?