NHLRC4 and SPAG8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NHLRC4	SPAG8
Description		NHL repeat containing 4	sperm associated antigen 8
Image		No pdb structure
GO Annotations	Cellular Component		Acrosomal Vesicle Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Axonemal Microtubule Cilium Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process		Spermatogenesis Single Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 27863252)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		20 interacting genes: CERK DDIT4L DMRT3 DTX2 ENKD1 HSF4 IGFN1 KRTAP13-2 KRTAP15-1 KRTAP26-1 MGAT5B MYLIP OTX1 PATZ1 PITX1 POGZ POU4F3 PRKAB2 SPAG8 TLX3	87 interacting genes: ACTMAP ARMC5 B9D2 BATF2 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581
Entrez ID		283948	26206
HPRD ID		11681	12039
Ensembl ID		ENSG00000257108	ENSG00000137098
Uniprot IDs		P0CG21	A0A140VJV0 Q99932
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diencephalon Morphogenesis Neuron Fate Specification Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Intermediate Filament	Intermediate Filament Protein-arginine N-methyltransferase Activity Protein Binding Histone Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylation Methyltransferase Activity Methylosome Protein Methylation Histone Arginine N-methyltransferase Activity MRNA Cleavage And Polyadenylation Specificity Factor Complex Keratin Filament Histone H3K9me/H3K9me2 Demethylase Activity Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation Macromolecule Methylation
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