TSSK4 and SMURF2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		TSSK4	SMURF2
Description		testis specific serine kinase 4	SMAD specific E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cilium Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Fertilization Cell Differentiation Flagellated Sperm Motility Positive Regulation Of CREB Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways			Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		3 interacting genes: CREB1 SMURF2 TGFBR1	94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		283629	64750
HPRD ID		12642	06901
Ensembl ID		ENSG00000139908	ENSG00000108854
Uniprot IDs		Q6SA08	Q96DE7 Q9HAU4
PDB IDs			1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q
Enriched GO Terms of Interacting Partners?		Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus SMAD Binding Protein Modification Process Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Developmental Growth Positive Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Protein Phosphorylation Positive Regulation Of Growth Response To Growth Factor Gland Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Response To Hypobaric Hypoxia Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Response To Alcohol Chemotaxis To Arachidonate Lung Saccule Development Response To Erythropoietin Regulation Of Testosterone Biosynthetic Process Membrane Raft Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex Positive Regulation Of Trophoblast Cell Migration Arrestin Family Protein Binding Type I Pneumocyte Differentiation Cell Surface Receptor Signaling Pathway	Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding
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