KCTD21 and PPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCTD21	PPL
Description		potassium channel tetramerization domain containing 21	periplakin
Image		No pdb structure
GO Annotations	Cellular Component		Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Identical Protein Binding Histone Deacetylase Binding Cullin Family Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways			Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Cancer ( 29299148) Diastolic blood pressure ( 27841878 28135244) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: C22orf15 CRLF3 KCTD15 LONRF1 NMRK1 NTAQ1 PPL RNF25 UFM1 ZMYND19	44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		283219	5493
HPRD ID		18763	04187
Ensembl ID		ENSG00000188997	ENSG00000118898
Uniprot IDs		Q4G0X4	O60437
PDB IDs			4Q28
Enriched GO Terms of Interacting Partners?			Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether
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