KCTD21 and RNF25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCTD21	RNF25
Description		potassium channel tetramerization domain containing 21	ring finger protein 25
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Cytosol Cytosolic Ribosome
	Molecular Function	Protein Binding Identical Protein Binding Histone Deacetylase Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding NF-kappaB Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	Translational Elongation Translational Termination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination Protein-RNA Covalent Cross-linking Repair
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)	Male-pattern baldness ( 28196072)
Interacting Genes		10 interacting genes: C22orf15 CRLF3 KCTD15 LONRF1 NMRK1 NTAQ1 PPL RNF25 UFM1 ZMYND19	10 interacting genes: KCTD21 MEOX2 RELA TRIM27 UBE2D1 UBE2D2 UBE2D4 UBE2E2 UBE2L6 UBE2U
Entrez ID		283219	64320
HPRD ID		18763	09737
Ensembl ID		ENSG00000188997	ENSG00000163481
Uniprot IDs		Q4G0X4	Q96BH1
PDB IDs			2DAY 2DMF 5D1K 5D1L 5D1M
Enriched GO Terms of Interacting Partners?			Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transferase Activity Proteolysis Involved In Protein Catabolic Process ISG15 Transferase Activity ISG15-protein Conjugation Protein K63-linked Ubiquitination Macromolecule Metabolic Process Proteolysis Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination ATP Binding NF-kappaB P50/p65 Complex Ubiquitin Protein Ligase Activity Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Nucleotide Binding Somite Specification Postsynapse To Nucleus Signaling Pathway Histone Deacetylase Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity HULC Complex
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