KCTD21 and NMRK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCTD21	NMRK1
Description		potassium channel tetramerization domain containing 21	nicotinamide riboside kinase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Histone Deacetylase Binding Cullin Family Protein Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Nicotinate Riboside Kinase Activity Metal Ion Binding Ribosylnicotinamide Kinase Activity Ribosylnicotinate Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization	NADP+ Biosynthetic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process NAD+ Metabolic Process NAD+ Biosynthetic Process Via The Salvage Pathway
Pathways			Nicotinate metabolism
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)	Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Urinary magnesium-to-creatinine ratio ( 29093028)
Interacting Genes		10 interacting genes: C22orf15 CRLF3 KCTD15 LONRF1 NMRK1 NTAQ1 PPL RNF25 UFM1 ZMYND19	5 interacting genes: APP INCA1 KCTD21 REL TAX1BP1
Entrez ID		283219	54981
HPRD ID		18763	09868
Ensembl ID		ENSG00000188997	ENSG00000106733
Uniprot IDs		Q4G0X4	B3KUG3 Q5W125 Q9NWW6
PDB IDs			2P0E 2QG6 2QL6 2QSY 2QSZ 2QT0 2QT1
Enriched GO Terms of Interacting Partners?			Protein Homooligomerization Protein Complex Oligomerization Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Innate Immune Response Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Defense Response To Symbiont Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Axon Midline Choice Point Recognition Defense Response To Other Organism Amylin Binding Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Signaling Identical Protein Binding Positive Regulation Of Protein Glycosylation NF-kappaB Complex Protein Localization To Phagocytic Vesicle Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Golgi Disassembly Axon Choice Point Recognition Regulation Of Protein Glycosylation Heparan Sulfate Binding Signaling Receptor Activator Activity
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