NPBWR2 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NPBWR2	KRTAP1-3
Description		neuropeptides B and W receptor 2	keratin associated protein 1-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding Neuropeptide Receptor Activity Neuropeptide Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway G Protein-coupled Opioid Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Keratinization
Drugs
Diseases
GWAS		Body mass index ( 25673413) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		18 interacting genes: BOLL CYSRT1 KPRP KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP6-2 NOTCH2NLA NPB NPW PHAF1 PNMA1 PSMA3	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		2832	81850
HPRD ID		02841	12305
Ensembl ID		ENSG00000125522	ENSG00000221880
Uniprot IDs		P48146	Q8IUG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Establishment Of Skin Barrier Tissue Development Structural Molecule Activity Skin Epidermis Development	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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