GPLD1 and GM2A

Number of citations of the paper that reports this interaction (PMID 10752311)
0

Data Source:
HPRD (in vitro)

		GPLD1	GM2A
Gene Name		glycosylphosphatidylinositol specific phospholipase D1	GM2 ganglioside activator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytoplasm Lysosomal Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Mitochondrion Hydrogen:potassium-exchanging ATPase Complex Cytoplasmic Side Of Plasma Membrane Lysosomal Lumen Apical Cortex Extracellular Vesicular Exosome
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Lipid Transporter Activity Phospholipase Activator Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway GPI Anchor Release Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Cytolysis Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Small Molecule Metabolic Process Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs			Platelet Activating Factor Lpc-Ether Glycerylphosphorylcholine MYRISTIC ACID
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757)	Bulimia nervosa ( 23568457)
Protein-Protein Interactions		5 interactors: ALPP APOA1 APOA4 CD55 GM2A	3 interactors: GPLD1 HEXA PLD2
Entrez ID		2822	2760
HPRD ID		03946	02034
Ensembl ID		ENSG00000112293	ENSG00000196743
Uniprot IDs		P80108	P17900
PDB IDs			1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Esterification Phospholipid Efflux Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Regulation Of Triglyceride Metabolic Process Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Lipid Localization Lipid Storage Sterol Biosynthetic Process Neuron Projection Regeneration Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Regulation Of Fatty Acid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process	Cellular Lipid Metabolic Process Glycolipid Metabolic Process GPI Anchor Release Cellular Response To Triglyceride Lipid Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Membrane Lipid Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytolysis Glycerophospholipid Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Glycerolipid Metabolic Process Phospholipid Metabolic Process Response To Triglyceride Small Molecule Metabolic Process Immune Response-regulating Signaling Pathway Keratan Sulfate Catabolic Process G-protein Coupled Receptor Internalization Phosphatidylglycerol Biosynthetic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Hyaluronan Catabolic Process Chondroitin Sulfate Catabolic Process Transepithelial Transport Cellular Response To PH Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Cholesterol Positive Regulation Of Immune Response Cellular Response To Sterol Regulation Of Triglyceride Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Response To Cholesterol Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Keratan Sulfate Metabolic Process Positive Regulation Of Phosphatase Activity Regulation Of Immune Response Blood Vessel Endothelial Cell Migration Positive Regulation Of Immune System Process Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Response To PH Synaptic Vesicle Recycling
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