GPLD1

Name	glycosylphosphatidylinositol specific phospholipase D1
Structure	No pdb structure
Interactors	5 interactors: ALPP APOA1 APOA4 CD55 GM2A
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Hydrolase Activity Sodium Channel Regulator Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Secretion Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To Xenobiotic Stimulus Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus
Pathways	Post-translational modification: synthesis of GPI-anchored proteins
GWAS	Hematological and biochemical traits ( 20139978 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301 )
Entrez ID	2822
HPRD ID	03946
Ensembl ID	ENSG00000112293
Uniprot IDs	P80108
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Lipid Transporter Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Chylomicron Regulation Of Intestinal Lipid Absorption Phospholipid Efflux Regulation Of Intestinal Absorption Low-density Lipoprotein Particle Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Cholesterol Transfer Activity Protein-lipid Complex Assembly Cholesterol Efflux Lipoprotein Metabolic Process Lipid Storage Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Acylglycerol Homeostasis Lipid Transport Lipid Binding Phosphatidylcholine Metabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Phospholipid Transport Extracellular Vesicle Sterol Homeostasis Cholesterol Homeostasis Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Cholesterol Metabolic Process Cell Surface Side Of Membrane Phospholipid Binding Sterol Metabolic Process Blood Microparticle Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Lipid Metabolic Process Organophosphate Ester Transport Regulation Of Lipid Transport Peptidyl-methionine Modification Positive Regulation Of Small Molecule Metabolic Process High-density Lipoprotein Particle Receptor Binding Organic Hydroxy Compound Transport Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Lipid Hydroperoxide