GPLD1 and CD55

Number of citations of the paper that reports this interaction (PMID 7512501)
17

Data Source:
HPRD (in vitro)

		GPLD1	CD55
Gene Name		glycosylphosphatidylinositol specific phospholipase D1	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytoplasm Lysosomal Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Virus Receptor Activity Protein Binding Lipid Binding
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway GPI Anchor Release Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Cytolysis Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Virus Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Regulation of Complement cascade Complement cascade Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Innate Immune System
Drugs			Chloramphenicol
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		5 interactors: ALPP APOA1 APOA4 CD55 GM2A	6 interactors: CD14 CD97 CR1 FYN GPLD1 LCK
Entrez ID		2822	1604
HPRD ID		03946	00500
Ensembl ID		ENSG00000112293	ENSG00000196352
Uniprot IDs		P80108	B1AP13 P08174
PDB IDs			1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Esterification Phospholipid Efflux Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Regulation Of Triglyceride Metabolic Process Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Lipid Localization Lipid Storage Sterol Biosynthetic Process Neuron Projection Regeneration Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Regulation Of Fatty Acid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process	Immune Response-regulating Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cell Surface Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Innate Immune Response Positive Regulation Of Proteolysis Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Metal Ion Response To Abiotic Stimulus Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Inorganic Substance T Cell Costimulation Response To Peptide Regulation Of Defense Response To Virus Response To Drug Signaling Movement Of Cell Or Subcellular Component Cell Communication GPI Anchor Release Cellular Response To Triglyceride Positive Regulation Of Serine-type Endopeptidase Activity Cellular Response To Hormone Stimulus T Cell Receptor Signaling Pathway Response To Stress Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Ethanol Positive Regulation Of Endopeptidase Activity Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Complement Activation, Alternative Pathway Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Positive Regulation Of Peptidase Activity
Tagcloud ?			abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Difference) ?			abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Intersection) ?