GPLD1 and ALPP

Number of citations of the paper that reports this interaction (PubMedID 11938765)
0

Data Source:
HPRD (in vitro)

		GPLD1	ALPP
Description		glycosylphosphatidylinositol specific phospholipase D1	alkaline phosphatase, placental
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome	Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Hydrolase Activity Sodium Channel Regulator Activity	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Secretion Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To Xenobiotic Stimulus Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Intra-Golgi traffic
Drugs			Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301)	Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A	47 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1
Entrez ID		2822	250
HPRD ID		03946	01379
Ensembl ID		ENSG00000112293	ENSG00000163283
Uniprot IDs		P80108	B2R7C7 P05187
PDB IDs			1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Lipid Transporter Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Chylomicron Regulation Of Intestinal Lipid Absorption Phospholipid Efflux Regulation Of Intestinal Absorption Low-density Lipoprotein Particle Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Cholesterol Transfer Activity Protein-lipid Complex Assembly Cholesterol Efflux Lipoprotein Metabolic Process Lipid Storage Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Acylglycerol Homeostasis Lipid Transport Lipid Binding Phosphatidylcholine Metabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Phospholipid Transport Extracellular Vesicle Sterol Homeostasis Cholesterol Homeostasis Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Cholesterol Metabolic Process Cell Surface Side Of Membrane Phospholipid Binding Sterol Metabolic Process Blood Microparticle Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Lipid Metabolic Process Organophosphate Ester Transport Regulation Of Lipid Transport Peptidyl-methionine Modification Positive Regulation Of Small Molecule Metabolic Process High-density Lipoprotein Particle Receptor Binding Organic Hydroxy Compound Transport Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Lipid Hydroperoxide	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding
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