GPLD1 and APOA4

Number of citations: 0 (PubMedID 11254757)
Data Source: HPRD (in vitro, in vivo)

		GPLD1	APOA4
Name		glycosylphosphatidylinositol specific phospholipase D1	apolipoprotein A4
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Hydrolase Activity Sodium Channel Regulator Activity	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Secretion Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To Xenobiotic Stimulus Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Innate Immune Response In Mucosa Lipid Transport Response To Stress Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Triglyceride Catabolic Process Peripheral Nervous System Axon Regeneration Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Triglyceride Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Lipid Homeostasis Acylglycerol Homeostasis Protein-lipid Complex Assembly
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		None	Zinc Copper Zinc acetate
GWAS		Hematological and biochemical traits ( 20139978 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301 )	Apolipoprotein A-IV levels ( 27412012 ) Body mass index ( 31978080 ) Cholesterol, total ( 19060911 20686565 ) Coronary artery disease ( 29263402 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 26582766 20864672 20686565 19060906 ) HDL cholesterol levels ( 28334899 ) Hematological and biochemical traits ( 20139978 ) Hypertriglyceridemia ( 23505323 ) LDL cholesterol ( 20686565 20864672 19060911 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 24386095 ) Metabolic syndrome ( 30382898 ) Metabolite levels ( 22916037 ) Postprandial triglyceride levels ( 32603185 ) Total cholesterol levels ( 29615537 28334899 29403010 ) Triglyceride levels ( 26763881 32335043 32203549 29615537 28371326 28334899 ) Triglycerides ( 20139978 20686565 20864672 19074352 19060911 19060906 21909109 26582766 18193044 18193043 )
Interacting Genes		5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A	6 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 HSP90AA1 MAGEA6
Entrez ID		2822	337
HPRD ID		03946	00130
Ensembl ID		ENSG00000112293	ENSG00000110244
Uniprot IDs		P80108	P06727
PDB IDs		Not available	3S84
GO Terms Enriched among Interactors		Lipid Transporter Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Chylomicron Regulation Of Intestinal Lipid Absorption Phospholipid Efflux Regulation Of Intestinal Absorption Low-density Lipoprotein Particle Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Cholesterol Transfer Activity Protein-lipid Complex Assembly Cholesterol Efflux Lipoprotein Metabolic Process Lipid Storage Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Acylglycerol Homeostasis Lipid Transport Lipid Binding Phosphatidylcholine Metabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Phospholipid Transport Extracellular Vesicle Sterol Homeostasis Cholesterol Homeostasis Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Cholesterol Metabolic Process Cell Surface Side Of Membrane Phospholipid Binding Sterol Metabolic Process Blood Microparticle Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Lipid Metabolic Process Organophosphate Ester Transport Regulation Of Lipid Transport Peptidyl-methionine Modification Positive Regulation Of Small Molecule Metabolic Process High-density Lipoprotein Particle Receptor Binding Organic Hydroxy Compound Transport Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Lipid Hydroperoxide	Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity CTP Binding DATP Binding Cellular Response To Triglyceride Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Histone Deacetylase Binding Positive Regulation Of High-density Lipoprotein Particle Clearance Rho GDP-dissociation Inhibitor Binding Positive Regulation Of Phosphatase Activity Negative Regulation Of Triglyceride Catabolic Process Response To Triglyceride Phospholipase D Activity Positive Regulation Of Dephosphorylation Hematopoietic Stem Cell Migration To Bone Marrow Sperm Mitochondrial Sheath Telomerase Holoenzyme Complex Assembly Angiotensin Type II Receptor Activity Positive Regulation Of Protein Catabolic Process Hematopoietic Stem Cell Migration Regulation Of Phosphatase Activity Positive Regulation Of Protein Transport Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding