GPLD1 and APOA4

Number of citations of the paper that reports this interaction (PMID 11254757)
2

Data Source:
HPRD (in vivo, in vitro)

		GPLD1	APOA4
Gene Name		glycosylphosphatidylinositol specific phospholipase D1	apolipoprotein A-IV
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Cytoplasm Lysosomal Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Lipid Transporter Activity Copper Ion Binding Protein Binding Lipid Binding Cholesterol Binding Antioxidant Activity Cholesterol Transporter Activity Phosphatidylcholine Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway GPI Anchor Release Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Cytolysis Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Retinoid Metabolic Process Innate Immune Response In Mucosa Cholesterol Biosynthetic Process Lipid Transport Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Phototransduction, Visible Light Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Neuron Projection Regeneration Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly Negative Regulation Of Plasma Lipoprotein Particle Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Protein-lipid Complex Assembly Triglyceride Homeostasis
Pathways
Drugs
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757)	Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		5 interactors: ALPP APOA1 APOA4 CD55 GM2A	1 interactors: GPLD1
Entrez ID		2822	337
HPRD ID		03946	00130
Ensembl ID		ENSG00000112293	ENSG00000110244
Uniprot IDs		P80108
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Esterification Phospholipid Efflux Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Positive Regulation Of Lipid Catabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Regulation Of Triglyceride Metabolic Process Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Lipid Localization Lipid Storage Sterol Biosynthetic Process Neuron Projection Regeneration Phosphatidylcholine Metabolic Process Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Plasma Lipoprotein Particle Levels Sterol Transport Cholesterol Transport Phototransduction, Visible Light Cholesterol Homeostasis Retinoid Metabolic Process Sterol Homeostasis Regulation Of Fatty Acid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Cholesterol Metabolic Process Lipid Homeostasis Steroid Biosynthetic Process	GPI Anchor Release Cellular Response To Triglyceride Positive Regulation Of High-density Lipoprotein Particle Clearance Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Positive Regulation Of Cytolysis Negative Regulation Of Triglyceride Catabolic Process Complement Receptor Mediated Signaling Pathway Response To Triglyceride Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To PH Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Cellular Response To Cholesterol Cellular Response To Sterol Regulation Of Triglyceride Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Response To Cholesterol Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Phosphatase Activity Blood Vessel Endothelial Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Response To PH Positive Regulation Of Dephosphorylation Cellular Response To Calcium Ion Phosphatidylcholine Metabolic Process Cellular Response To Drug Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Biosynthetic Process GPI Anchor Metabolic Process Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Insulin Secretion Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Peptide Hormone Secretion Endothelial Cell Migration Positive Regulation Of Peptide Secretion Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Response To Insulin Stimulus Chondrocyte Differentiation Epithelial Cell Migration Regulation Of Phosphatase Activity Epithelium Migration Positive Regulation Of Hormone Secretion Regulation Of Glucose Metabolic Process Regulation Of Endothelial Cell Migration
Tagcloud ?			2d apoa1 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Difference) ?			2d apoa1 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Intersection) ?