RGS5

Name	regulator of G protein signaling 5
Structure
Interactors	7 interactors: ADRB2 APP GNAI2 GNAI3 GNAO1 GNAQ MEOX2
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
GWAS	Height ( 28552196 ) Hypoalbuminemia ( 34050200 ) Lead levels in blood ( 25820613 ) Liver enzyme levels (alanine transaminase) ( 24124411 ) Motion sickness ( 25628336 ) Response to mTOR inhibitor (rapamycin) ( 24009623 )
Entrez ID	8490
HPRD ID	04471
Ensembl ID	ENSG00000143248
Uniprot IDs	O15539
PDB IDs	2CRP
GO Terms Enriched among Interactors ?	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Cell Body GTPase Activity GTP Binding Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP/PKA Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Ion Channel Signaling Pathway Acetylcholine Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Postsynaptic Signal Transduction Cellular Response To Amyloid-beta Ciliary Basal Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Amyloid-beta Regulation Of Metal Ion Transport Regulation Of Multicellular Organism Growth Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein Activity Regulation Of Monoatomic Ion Transport Positive Regulation Of MAPK Cascade Dendrite Positive Regulation Of Macroautophagy Beta2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity