KLHL22 and DEPDC5

Number of citations of the paper that reports this interaction (PubMedID 29769719)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		KLHL22	DEPDC5
Description		kelch like family member 22	DEP domain containing 5, GATOR1 subcomplex subunit
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Intercellular Bridge Mitotic Spindle	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	Protein Binding 14-3-3 Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	GTPase Activator Activity Protein Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Mitotic Sister Chromatid Segregation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Amino Acid Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Cell Division Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Cytoplasmic Translation Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Lung function (FEV1/FVC) ( 30061609) Retinopathy in non-diabetics ( 23393555)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment ( 33608531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)
Interacting Genes		6 interacting genes: ADRA1A CUL3 DEPDC5 GLUD1 PLK1 RBX1	11 interacting genes: CCT3 DPPA3 KLHL22 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2
Entrez ID		84861	9681
HPRD ID		07858	16795
Ensembl ID		ENSG00000099910	ENSG00000100150
Uniprot IDs		Q53GT1	A0A2R8Y5T1 A0A2R8Y6H3 A0A2R8Y6V4 H0Y770 O75140
PDB IDs		8K8T 8K9I 8KHP 8W4J	6CES 6CET 7T3A 7T3B 7T3C 8FW5
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Starvation Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Mitotic Cell Cycle Phase Transition Regulation Of TOR Signaling Cell Cycle Phase Transition RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Cellular Response To Starvation Renal Sodium Ion Transport Regulation Of Protein Ubiquitination Response To Starvation Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Nuclear RNA Surveillance Cellular Response To Nutrient Levels RNA Surveillance Renal Absorption Negative Regulation Of Type I Interferon Production Transcription Elongation By RNA Polymerase II Type I Interferon-mediated Signaling Pathway DNA-templated Transcription Elongation Protein Monoubiquitination Protein Destabilization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Autophagy Positive Regulation Of Protein Modification Process TORC1 Signaling Interferon-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Separation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Amino Acid Stimulus TOR Signaling Regulation Of Cytokinesis	Negative Regulation Of Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Autophagy Negative Regulation Of Mitotic Nuclear Division Gtr1-Gtr2 GTPase Complex Regulation Of Mitotic Sister Chromatid Separation Cellular Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Response To Amino Acid Starvation Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cellular Response To Amino Acid Stimulus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of TORC1 Signaling Regulation Of Sister Chromatid Segregation Response To Amino Acid Regulation Of Mitotic Nuclear Division Regulation Of Protein Stability Regulation Of Autophagy Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of TOR Signaling Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cellular Response To Starvation Regulation Of Mitotic Cell Cycle Mitotic Sister Chromatid Segregation GTPase Binding Negative Regulation Of Mitotic Cell Cycle Sister Chromatid Segregation Response To Starvation Negative Regulation Of Cell Cycle Phase Transition Protein Stabilization Nuclear Chromosome Segregation Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Cell Cycle Process Guanyl Ribonucleotide Binding DNA Damage Response, Signal Transduction Resulting In Transcription Cytoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization
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