KLHL22 and ADRA1A

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		KLHL22	ADRA1A
Description		kelch like family member 22	adrenoceptor alpha 1A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Cytoskeleton Cul3-RING Ubiquitin Ligase Complex Intercellular Bridge Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Nuclear Membrane
	Molecular Function	Protein Binding 14-3-3 Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Sister Chromatid Segregation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Amino Acid Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Cell Division Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	MAPK Cascade Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Regulation Of Muscle Contraction Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Vasoconstriction Positive Regulation Of Synaptic Transmission, GABAergic Organ Growth Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Pilomotor Reflex Neuron-glial Cell Signaling
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs			Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Lung function (FEV1/FVC) ( 30061609) Retinopathy in non-diabetics ( 23393555)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		6 interacting genes: ADRA1A CUL3 DEPDC5 GLUD1 PLK1 RBX1	30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8
Entrez ID		84861	148
HPRD ID		07858	00081
Ensembl ID		ENSG00000099910	ENSG00000120907
Uniprot IDs		Q53GT1	B0ZBD3 P35348
PDB IDs		8K8T 8K9I 8KHP 8W4J	7YM8 7YMH 7YMJ 8HN1 8THK 8THL
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Starvation Cul3-RING Ubiquitin Ligase Complex Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Mitotic Cell Cycle Phase Transition Regulation Of TOR Signaling Cell Cycle Phase Transition RNA Polymerase II Transcription Initiation Surveillance Renal Sodium Ion Absorption Cellular Response To Starvation Renal Sodium Ion Transport Regulation Of Protein Ubiquitination Response To Starvation Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Nuclear RNA Surveillance Cellular Response To Nutrient Levels RNA Surveillance Renal Absorption Negative Regulation Of Type I Interferon Production Transcription Elongation By RNA Polymerase II Type I Interferon-mediated Signaling Pathway DNA-templated Transcription Elongation Protein Monoubiquitination Protein Destabilization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Autophagy Positive Regulation Of Protein Modification Process TORC1 Signaling Interferon-mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Separation Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cellular Response To Amino Acid Stimulus TOR Signaling Regulation Of Cytokinesis	Membrane Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Alpha1-adrenergic Receptor Activity Calcium-mediated Signaling Interleukin-8 Binding Neuron-glial Cell Signaling G Protein-coupled Receptor Activity Regulation Of Blood Circulation C-X-C Chemokine Receptor Activity Adrenergic Receptor Activity Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor-mediated Endocytosis Dendritic Spine Membrane Receptor Internalization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Cardiac Muscle Contraction Dendritic Cell Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Signaling Cassette Adrenergic Receptor Signaling Pathway Regulation Of Striated Muscle Contraction Intercellular Bridge Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Immobilization Stress Dendritic Cell Migration Regulation Of MAPK Cascade Sarcolemma Muscle System Process Myoblast Fusion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Macrophage Fusion Cell-cell Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Syncytium Formation By Plasma Membrane Fusion Transmembrane Transporter Binding Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Positive Regulation Of Sodium Ion Transport Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Corticospinal Neuron Axon Guidance N-acylsphingosine Galactosyltransferase Activity
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