PRPF19 and PRPF8

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PRPF19	PRPF8
Gene Name		pre-mRNA processing factor 19	pre-mRNA processing factor 8
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding U6 SnRNA Binding U5 SnRNA Binding Poly(A) RNA Binding K63-linked Polyubiquitin Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3	14 interactors: ABCA1 DHX9 EFTUD2 ERG GPKOW HNRNPH2 NEDD4 PIN1 PRPF19 SERPINB2 SND1 SNRNP200 UBC ZNF830
Entrez ID		27339	10594
HPRD ID		12214	06295
Ensembl ID		ENSG00000110107	ENSG00000174231
Uniprot IDs		Q9UMS4	Q6P2Q9
PDB IDs		4LG8	3E9L 3ENB 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT
Enriched GO Terms of Interacting Partners?		DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Osteoblast Differentiation DNA Damage Checkpoint Blastocyst Growth Protein Polyubiquitination RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Response To Stress Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Negative Regulation Of Type I Interferon Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Ossification Cellular Nitrogen Compound Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Potassium Ion Transport Spliceosomal Complex Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Potassium Ion Export Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production Nitrogen Compound Metabolic Process Cis Assembly Of Pre-catalytic Spliceosome Regulation Of Heart Rate By Hormone Cellular Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Ion Transport Regulation Of Mitotic Cell Cycle
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp	abcb7 advance alas2 asxl1 bclaf1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?