PRPF19 and RPA2

Number of citations of the paper that reports this interaction (PMID 24332808)
3

Data Source:
BioGRID (enzymatic study)

		PRPF19	RPA2
Gene Name		pre-mRNA processing factor 19	replication protein A2, 32kDa
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break
	Molecular Function	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cellular Response To Heat Regulation Of DNA Damage Checkpoint
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3	49 interactors: ACP5 APP ATM CALCOCO2 CCNO CDC5L CDK1 CFB COPS6 CRMP1 EEF1A1 EIF4G2 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 KIAA1377 LRIF1 MCM2 MCM3 MCM4 MCM5 MED31 MEN1 ORC1 ORC2 ORC4 ORC5 PRKDC PRPF19 RAD1 RAD52 RAD9A RBM48 RFWD3 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA
Entrez ID		27339	6118
HPRD ID		12214	01566
Ensembl ID		ENSG00000110107	ENSG00000117748
Uniprot IDs		Q9UMS4	P15927
PDB IDs		4LG8	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle	DNA Metabolic Process Cell Cycle Process Cell Cycle DNA Replication Heterocycle Metabolic Process DNA Replication Initiation Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication DNA Repair G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Damage Checkpoint DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To Stress Cell Cycle Checkpoint Response To Radiation Cellular Metabolic Process Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair Regulation Of Cell Cycle DNA Recombinase Assembly Response To Abiotic Stimulus DNA Recombination DNA Catabolic Process Cellular Macromolecule Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Aromatic Compound Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Signal Transduction Involved In DNA Damage Checkpoint Metabolic Process
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp	53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp	53bp1 accurately atm azd2281 brca1 brca2 characterizing cyclina2 ddr deficiencies distngiushed etoposide functionality genotoxins h2ax haploinsuffiency hrr joining mechanistically muted nhej normalize parpi pkcs predisposition proficient readouts scnp temozolomide
Tagcloud (Intersection) ?