PRPF19 and DDX42

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF19	DDX42
Gene Name		pre-mRNA processing factor 19	DEAD (Asp-Glu-Ala-Asp) box helicase 42
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Particle Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cajal Body Membrane Nuclear Speck
	Molecular Function	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Double-strand Break Repair Via Nonhomologous End Joining RNA Splicing Lipid Biosynthetic Process Gene Expression Proteasomal Protein Catabolic Process Cellular Protein Localization Negative Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	Protein Localization Metabolic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BCAS2 CDC5L DDX42 DNTT EGLN3 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA1 RPA2 RPA3 U2AF1 UBE2D3	10 interactors: APP DHX15 FBXO25 PRPF19 RECQL5 SF3A1 SF3B4 SNRPC U2SURP UBC
Entrez ID		27339	11325
HPRD ID		12214	09909
Ensembl ID		ENSG00000110107	ENSG00000198231
Uniprot IDs		Q9UMS4	Q86XP3
PDB IDs		4LG8
Enriched GO Terms of Interacting Partners?		DNA Recombinase Assembly Transcription-coupled Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleotide-excision Repair Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Repair RNA Splicing Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing Mismatch Repair Base-excision Repair Cellular Response To Heat Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition RNA Processing Cell Cycle Process DNA-dependent DNA Replication Response To Heat Heterocycle Metabolic Process Mitotic Cell Cycle Process DNA Catabolic Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Double-strand Break Repair Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Protein-DNA Complex Assembly Response To Stress Cell Cycle	RNA Processing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Splicing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Regulation Of Cell Cycle Phase Transition Spliceosomal SnRNP Assembly Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway MRNA Splice Site Selection Cellular Metabolic Process Ribonucleoprotein Complex Biogenesis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Generation Of Catalytic Spliceosome For First Transesterification Step Regulation Of ERBB Signaling Pathway Regulation Of MRNA Processing Signal Transduction In Response To DNA Damage Regulation Of RNA Splicing Synaptic Growth At Neuromuscular Junction Regulation Of Cell Cycle Process Collateral Sprouting In Absence Of Injury Protein Ubiquitination Notch Signaling Pathway MRNA 5'-splice Site Recognition DNA Repair Protein Modification By Small Protein Conjugation DNA Damage Checkpoint Cellular Macromolecular Complex Assembly Collateral Sprouting Axon Midline Choice Point Recognition MRNA 3'-splice Site Recognition Protein Polyubiquitination Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Gene Expression Axon Choice Point Recognition Negative Regulation Of Neuron Differentiation
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?