CLDN7 and HGD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CLDN7	HGD
Description		claudin 7	homogentisate 1,2-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Anchoring Junction	Cytosol Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Homogentisate 1,2-dioxygenase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tyrosine Metabolic Process L-tyrosine Catabolic Process
Pathways		Tight junction interactions	Tyrosine catabolism
Drugs
Diseases			Alkaptonuria
GWAS		Birth weight ( 27680694 31043758) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758)
Interacting Genes		77 interacting genes: AIG1 ANKRD46 APOD AQP2 ASGR1 BCL2L2 BET1 BMP10 C3orf52 CD53 CD72 CLN6 CMTM5 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB561D2 CYB5B CYBC1 EDDM3B EMP3 EPCAM ERG28 ERMP1 FAXDC2 FXYD6 GIMAP5 GLP1R GPR37L1 HGD IGFBP5 ITM2A JAGN1 LAT LEPROTL1 LPAR3 LSMEM2 MAL MALL MS4A13 NDUFB11 NIPAL4 NKG7 OLFM4 PGAP2 PLN RHOXF2 RPRM RTP2 SCAMP4 SCARF1 SEC22B SERTM1 SLC38A7 SLC61A1 SYNE4 TJP1 TMEM100 TMEM11 TMEM128 TMEM140 TMEM147 TMEM44 TMEM60 TMEM97 TNF TRARG1 TSPAN33 UBIAD1 UNC93B1 UPK1B UPK2 VAMP3 VAMP5 VSTM1	5 interacting genes: CLDN7 GIT2 NTAQ1 PCDHGC3 TERF1
Entrez ID		1366	3081
HPRD ID		07633	06315
Ensembl ID		ENSG00000181885	ENSG00000113924
Uniprot IDs		A0A384ME58 F5H496 O95471	B3KW64 Q93099
PDB IDs			1EY2 1EYB
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Localization Within Membrane Transmembrane Ascorbate Ferrireductase Activity	Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein-N-terminal Asparagine Amidohydrolase Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Establishment Of Protein Localization To Chromosome Nuclear Telomere Cap Complex Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Telomere Localization Shelterin Complex Meiotic Telomere Clustering Telomeric D-loop Disassembly Ankyrin Repeat Binding Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Arachidonate-CoA Ligase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Synaptic Vesicle Recycling Long-chain Fatty Acid-CoA Ligase Activity DNA Binding, Bending Regulation Of ARF Protein Signal Transduction Long-chain Fatty-acyl-CoA Biosynthetic Process Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Apicolateral Plasma Membrane Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Long-chain Fatty-acyl-CoA Metabolic Process
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