SLC39A1 and CERS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SLC39A1	CERS2
Description		solute carrier family 39 member 1	ceramide synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Signaling Receptor Binding Zinc Ion Transmembrane Transporter Activity Protein Binding Inorganic Cation Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	In Utero Embryonic Development Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Metal Ion Transport Embryonic Cranial Skeleton Morphogenesis Transmembrane Transport Limb Development Zinc Ion Transmembrane Transport	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways		Zinc influx into cells by the SLC39 gene family	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Lentiform nucleus volume ( 22903471) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31015462 31152163) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		16 interacting genes: CERS2 COMT CXCL16 CXCL9 CYB561 HTR2C HTR4 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2 TRARG1 YIPF6	15 interacting genes: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 UBC YIF1A
Entrez ID		27173	29956
HPRD ID		11984	06080
Ensembl ID		ENSG00000143570	ENSG00000143418
Uniprot IDs		A0A0A0MTL8 Q9NY26	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Serotonin Binding Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Juxtaparanode Region Of Axon Alcohol Dehydrogenase (NADP+) Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite Positive Regulation Of T-helper Cell Differentiation Behavioral Fear Response Behavioral Defense Response Plasma Membrane Norepinephrine Secretion Fear Response Catechol O-methyltransferase Activity Large Intestinal Transit Chemokine Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Potassium Channel Regulator Activity Pinceau Fiber Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Regulation Of T-helper Cell Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Voltage-gated Potassium Channel Activity Positive Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Phosphate Starvation Cell-cell Signaling Cell Communication Response To Peptide Hormone Multicellular Organismal Response To Stress Signaling Digestive System Process Chemical Synaptic Transmission Ascorbate Homeostasis Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Transmembrane Transport Regulation Of Cell Differentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Activation	Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding
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