SLC39A1 and PLEKHM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SLC39A1	PLEKHM2
Gene Name		solute carrier family 39 (zinc transporter), member 1	pleckstrin homology domain containing, family M (with RUN domain) member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane	Cytoplasm
	Molecular Function	Receptor Binding Zinc Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity	Protein Binding Kinesin Binding
	Biological Process	Cation Transport Transmembrane Transport Zinc Ion Transmembrane Transport	Golgi Organization
Pathways		Metal ion SLC transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Zinc influx into cells by the SLC39 gene family Zinc transporters SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Lentiform nucleus volume ( 22903471)
Protein-Protein Interactions		8 interactors: CERS2 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2	2 interactors: KLC1 SLC39A1
Entrez ID		27173	23207
HPRD ID		11984	11440
Ensembl ID		ENSG00000143570	ENSG00000116786
Uniprot IDs		B4DDY7 Q9NY26	Q5VVD7 Q8IWE5
PDB IDs			3CXB 3HW2 3ZFW
Enriched GO Terms of Interacting Partners?		Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Synaptic Transmission Protein Heterooligomerization Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production NADPH Oxidation Activation Of Phospholipase D Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Metal Ion Transport Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Cell-cell Signaling Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of T Cell Cytokine Production Cation Transmembrane Transport Positive Regulation Of T-helper 2 Cell Differentiation Glomerular Capillary Formation Learning Or Memory Regulation Of Interleukin-10 Secretion Cognition Positive Regulation Of Interleukin-4 Production Positive Regulation Of Insulin Receptor Signaling Pathway Angiogenesis Regulation Of T Cell Cytokine Production Cation Transport Regulation Of Interleukin-5 Production Glomerulus Morphogenesis Positive Regulation Of Type 2 Immune Response	Stress Granule Disassembly Protein Localization To Synapse Zinc Ion Transmembrane Transport Zinc Ion Transport Organelle Disassembly Axon Cargo Transport
Tagcloud ?		aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic	accounted attenuating effector enterica hydrolytic lysosomal lysosome lysosomes mannose mpr mprs noninfected pathogen potency rab9 replicates retrograde salmonella sequestration sifa skip subverted thereby trafficking translocated transported undergo vacuoles whose
Tagcloud (Difference) ?		aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic	accounted attenuating effector enterica hydrolytic lysosomal lysosome lysosomes mannose mpr mprs noninfected pathogen potency rab9 replicates retrograde salmonella sequestration sifa skip subverted thereby trafficking translocated transported undergo vacuoles whose
Tagcloud (Intersection) ?