TJP3 and CLDN1

Number of citations of the paper that reports this interaction (PubMedID 10601346)
52

Data Source:
HPRD (in vitro, in vivo)

		TJP3	CLDN1
Description		tight junction protein 3	claudin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Protein-containing Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding	Virus Receptor Activity Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Cell Adhesion Establishment Of Blood-nerve Barrier Response To Toxic Substance Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Positive Regulation Of Cell Migration Response To Lipopolysaccharide Cell Junction Maintenance Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Response To Ethanol Symbiont Entry Into Host Cell Protein Complex Oligomerization Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Establishment Of Skin Barrier Xenobiotic Transport Across Blood-nerve Barrier Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Lead Ion Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Response To Dexamethasone Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Wound Healing Establishment Of Endothelial Intestinal Barrier Liver Regeneration Positive Regulation Of Bicellular Tight Junction Assembly Cellular Response To Butyrate
Pathways			Tight junction interactions
Drugs
Diseases			Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)	Optic disc size ( 31809533) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		5 interacting genes: CLDN1 FASLG GJC1 PATJ TJP1	18 interacting genes: BRD4 CD69 CD79A CLDN3 DRG1 FNDC9 LNX1 MMP14 MMP2 MPDZ MS4A3 PATJ TJP1 TJP2 TJP3 TMEM179B TMEM9 WNK4
Entrez ID		27134	9076
HPRD ID		18194	04760
Ensembl ID		ENSG00000105289	ENSG00000163347
Uniprot IDs		O95049	A5JSJ9 O95832
PDB IDs		3KFV
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Assembly Cell-cell Junction Organization Tight Junction Cell Junction Assembly Anchoring Junction Cell Junction Organization Bicellular Tight Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Bicellular Tight Junction Assembly Cell Junction Gap Junction Apical Junction Complex Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Cellular Component Maintenance Cellular Response To Type II Interferon Apical Part Of Cell Xenobiotic Transport Across Blood-nerve Barrier Response To Type II Interferon Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Epithelial Cell Development Cellular Response To Butyrate SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Retinal Cell Programmed Cell Death Response To Butyrate Cellular Response To Lead Ion Response To Interleukin-18 Establishment Of Blood-nerve Barrier Cytoplasmic Vesicle Lumen Anatomical Structure Homeostasis Tissue Homeostasis AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Cell Development Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipid Translocation Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Inflammatory Cell Apoptotic Process Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Cellular Component Assembly Basolateral Plasma Membrane	Bicellular Tight Junction Tight Junction Positive Regulation Of Blood-brain Barrier Permeability Cell-cell Junction Organization Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Anchoring Junction Endothelial Cell Development Regulation Of Blood-brain Barrier Permeability Cell Junction Organization Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability Protein Localization To Cell-cell Junction Apical Junction Complex Cell-cell Junction Assembly Epithelial Cell Development Regulation Of Vascular Permeability Tight Junction Assembly Membrane Tight Junction Organization Anatomical Structure Homeostasis Tissue Homeostasis Protein Localization To Cell Junction Apical Part Of Cell Multicellular Organismal-level Homeostasis Cell Adhesion Molecule Binding Cell Junction Assembly Vascular Process In Circulatory System Cell-cell Junction Maintenance Apicolateral Plasma Membrane Circulatory System Process Plasma Membrane Regulation Of T-helper 17 Cell Differentiation Endodermal Cell Differentiation Regulation Of T-helper 17 Type Immune Response Collagen Catabolic Process Regulation Of Cell Adhesion Regulation Of Cell Fate Commitment Ovarian Follicle Development Extracellular Matrix Disassembly Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Cell Junction Histone H4K8ac Reader Activity Aldosterone Secretion Regulation Of T-helper Cell Differentiation Cell Junction Maintenance Regulation Of Lymphocyte Differentiation Homeostatic Process Transmembrane Signaling Receptor Activity
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