TJP3 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 9531559)
48

Data Source:
HPRD (in vitro)

		TJP3	TJP1
Description		tight junction protein 3	tight junction protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly
Pathways			Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216)	Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)
Interacting Genes		5 interacting genes: CLDN1 FASLG GJC1 PATJ TJP1	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3
Entrez ID		27134	7082
HPRD ID		18194	03002
Ensembl ID		ENSG00000105289	ENSG00000104067
Uniprot IDs		O95049	A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157
PDB IDs		3KFV	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Assembly Cell-cell Junction Organization Tight Junction Cell Junction Assembly Anchoring Junction Cell Junction Organization Bicellular Tight Junction Establishment Of Endothelial Intestinal Barrier Regulation Of Bicellular Tight Junction Assembly Cell Junction Gap Junction Apical Junction Complex Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell Junction Maintenance Tight Junction Assembly Tight Junction Organization Cellular Component Maintenance Cellular Response To Type II Interferon Apical Part Of Cell Xenobiotic Transport Across Blood-nerve Barrier Response To Type II Interferon Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Epithelial Cell Development Cellular Response To Butyrate SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Retinal Cell Programmed Cell Death Response To Butyrate Cellular Response To Lead Ion Response To Interleukin-18 Establishment Of Blood-nerve Barrier Cytoplasmic Vesicle Lumen Anatomical Structure Homeostasis Tissue Homeostasis AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication Cell Development Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipid Translocation Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Inflammatory Cell Apoptotic Process Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Cellular Component Assembly Basolateral Plasma Membrane	Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process
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