NOX1 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NOX1	TBXA2R
Description		NADPH oxidase 1	thromboxane A2 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Plasma Membrane Membrane Cell Projection NADPH Oxidase Complex Anchoring Junction	Acrosomal Vesicle Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Small GTPase Binding Metal Ion Binding NADP Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity	G Protein-coupled Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP+ Metabolic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Smooth Muscle Contraction Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Regulation Of Vasoconstriction Positive Regulation Of Blood Coagulation Response To Lipopolysaccharide Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs		Oxygen	Ridogrel Seratrodast Morniflumate
Diseases
GWAS
Interacting Genes		6 interacting genes: ARHGEF7 CYBA FBXW7 NOXA1 NOXO1 TBXA2R	35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 SLC61A1 TM4SF4 VRK2 YWHAZ ZDHHC15
Entrez ID		27035	6915
HPRD ID		02203	01768
Ensembl ID		ENSG00000007952	ENSG00000006638
Uniprot IDs		A6NGA6 Q1ZYL4 Q9Y5S8	P21731 Q05C92 Q0VAB0
PDB IDs			8XJN 8XJO
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Positive Regulation Of Blood Pressure Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Microtubule Nucleation SH3 Domain Binding Regulation Of Renal Output By Angiotensin Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Cellular Response To L-glutamine Regulation Of Blood Pressure Cellular Response To Radiation Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mucus Secretion Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development Regulation Of Blood Volume By Renin-angiotensin Smooth Muscle Adaptation Response To Ketone Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Lamellipodium Morphogenesis Regulation Of Mucus Secretion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Muscle System Process Ubiquitin-protein Transferase Activator Activity Regulation Of Osteoclast Development Hydrogen Peroxide Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Body Fluid Levels Cellular Response To Phorbol 13-acetate 12-myristate Response To Alcohol Regulation Of Lamellipodium Morphogenesis Regulation Of SREBP Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Defense Response To Bacterium	Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Activity G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E G Protein-coupled Receptor Binding Plasma Membrane Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Membrane Regulation Of Cell Communication Regulation Of Signaling Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Extracellular Exosome Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus GTP Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Catecholamine Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Prostaglandin Stimulus Nucleotide Binding Cellular Response To PH Beta-adrenergic Receptor Kinase Activity Adenylate Cyclase Activator Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Protein Phosphorylation Response To PH Response To Ketone G Protein-coupled Receptor Kinase Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Phosphorylation Response To Alcohol Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Phototransduction, Visible Light Photoreceptor Outer Segment Negative Regulation Of Programmed Cell Death Regulation Of Blood Pressure Cellular Response To Acidic PH
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