NOX1 and NOXO1

Number of citations of the paper that reports this interaction (PubMedID 16329988)
0

Data Source:
BioGRID (pull down)

		NOX1	NOXO1
Description		NADPH oxidase 1	NADPH oxidase organizer 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Plasma Membrane Membrane Cell Projection NADPH Oxidase Complex Anchoring Junction	Cytoplasm Plasma Membrane Membrane NADPH Oxidase Complex
	Molecular Function	Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Small GTPase Binding Metal Ion Binding NADP Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity	Protein Binding Phospholipid Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Enzyme Binding Phosphatidylinositol Binding
	Biological Process	MAPK Cascade Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP+ Metabolic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Superoxide Anion Generation Regulation Of Respiratory Burst
Pathways		RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping	RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Oxygen	Ecabet
Diseases
GWAS			Red cell distribution width ( 32888494)
Interacting Genes		6 interacting genes: ARHGEF7 CYBA FBXW7 NOXA1 NOXO1 TBXA2R	2 interacting genes: NOX1 NOXA1
Entrez ID		27035	124056
HPRD ID		02203	14834
Ensembl ID		ENSG00000007952	ENSG00000196408
Uniprot IDs		A6NGA6 Q1ZYL4 Q9Y5S8	A8K832 Q8NFA2
PDB IDs			2L73
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Positive Regulation Of Blood Pressure Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Negative Regulation Of Microtubule Nucleation SH3 Domain Binding Regulation Of Renal Output By Angiotensin Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Cellular Response To L-glutamine Regulation Of Blood Pressure Cellular Response To Radiation Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mucus Secretion Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development Regulation Of Blood Volume By Renin-angiotensin Smooth Muscle Adaptation Response To Ketone Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Lamellipodium Morphogenesis Regulation Of Mucus Secretion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Muscle System Process Ubiquitin-protein Transferase Activator Activity Regulation Of Osteoclast Development Hydrogen Peroxide Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Body Fluid Levels Cellular Response To Phorbol 13-acetate 12-myristate Response To Alcohol Regulation Of Lamellipodium Morphogenesis Regulation Of SREBP Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Defense Response To Bacterium	NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Small GTPase Binding Oxygen Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Superoxide-generating NADPH Oxidase Activity Cellular Response To Hyperoxia Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Superoxide-generating NAD(P)H Oxidase Activity NAD(P)H Oxidase H2O2-forming Activity Cellular Response To Increased Oxygen Levels Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Response To Hyperoxia Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Respiratory Burst Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vascular Endothelial Growth Factor Production Hydrogen Peroxide Metabolic Process NADP+ Metabolic Process NADP Binding Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway JNK Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of JNK Cascade SH3 Domain Binding Nicotinamide Nucleotide Metabolic Process
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