LHFPL5 and CLDN22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHFPL5	CLDN22
Description		LHFPL tetraspan subfamily member 5	claudin 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane Stereocilium Bundle Stereocilium Tip	Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Auditory Receptor Cell Stereocilium Organization	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Tight junction interactions
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494)
Interacting Genes		131 interacting genes: ADGRG3 APOL3 AQP2 AQP6 AQP9 ARL13B BTN2A2 C14orf180 C1GALT1 C3orf52 C5orf46 CD37 CD53 CD72 CD79A CD81 CDS2 CERS4 CLCN7 CLDN22 CLDN5 CLDND2 CLEC14A CMTM7 CPLX4 CREB3 CREB3L1 CTXN3 CXCL16 CYB561 DAGLA ELOVL4 EMP1 EMP3 ENTPD3 ERG28 ERGIC3 FAM209A FCGR1A FFAR2 FNDC9 FXYD6 GJA8 GJB2 GJB3 GJB4 GJB6 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HAS3 HLA-DQA2 HSD17B13 INSIG2 ITGB2 JAGN1 KASH5 KCNK5 KIR2DL3 KTN1 LAT LIME1 LMNA LNPEP LPAR3 LRRC25 LRRC4C MFF MIP MS4A13 MTIF3 NINJ2 NIPAL4 NKG7 NRG4 PDZK1IP1 PLLP PLP1 PLP2 RMDN3 RPRM RUSF1 SAR1A SCN3B SEC22A SEC22B SERP1 SERP2 SERTM1 SLC16A2 SLC34A2 SLC35A1 SLC35B4 SLC35H1 SLC41A1 SLC61A1 SMIM1 SSMEM1 SYNJ2BP TEX264 TFRC TIMMDC1 TM4SF18 TM4SF4 TMEM100 TMEM107 TMEM128 TMEM201 TMEM218 TMEM229B TMEM248 TMEM254 TMEM31 TMEM42 TMEM50B TMEM52B TMEM60 TMEM86A TMEM97 TMX1 TMX2 TRARG1 TSPAN33 TSPAN7 TSPO UBIAD1 VAMP3 VMA21 ZDHHC15	7 interacting genes: CLEC4C CXCR2 LHFPL5 OPRM1 SPG21 TMBIM6 TREX1
Entrez ID		222662	53842
HPRD ID		13989	13068
Ensembl ID		ENSG00000197753	ENSG00000177300
Uniprot IDs		Q8TAF8	Q8N7P3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Gap Junction-mediated Intercellular Transport Intercellular Transport Connexin Complex Endoplasmic Reticulum Membrane Endoplasmic Reticulum Gap Junction Channel Activity Gap Junction Water Channel Activity Water Transport Bleb Assembly Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Fluid Transport Channel Activity B Cell Receptor Complex Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Immunological Synapse	Negative Regulation Of Cytosolic Calcium Ion Concentration Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Regulation Of Immunoglobulin Production Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Interleukin-8 Receptor Activity Secretory Granule Membrane Interleukin-8-mediated Signaling Pathway Endoribonuclease Inhibitor Activity Cellular Response To Type I Interferon DNA Exonuclease Activity Retrotransposition Transposition Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Interleukin-8 Binding Myeloid Leukocyte Activation Cellular Response To Morphine DNA Synthesis Involved In UV-damage Excision Repair Mast Cell Granule Membrane Regulation Of NMDA Receptor Activity System Process T Cell Antigen Processing And Presentation Negative Regulation Of Calcium Ion Transport Into Cytosol G Protein-coupled Opioid Receptor Activity Calcium Ion Transmembrane Transport Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response MutSalpha Complex Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity MutLalpha Complex Binding C-X-C Chemokine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Immune System Process Behavioral Response To Ethanol Calcium Ion Transport G Protein-coupled Opioid Receptor Signaling Pathway Nervous System Process IRE1-mediated Unfolded Protein Response 3'-5'-DNA Exonuclease Activity CD4 Receptor Binding Stereocilium Bundle Monoatomic Ion Transport Negative Regulation Of Immunoglobulin Production Cellular Response To Hydroxyurea
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