PROKR2 and FNDC9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PROKR2	FNDC9
Description		prokineticin receptor 2	fibronectin type III domain containing 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane
	Molecular Function	G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Circadian Rhythm Cellular Response To Hormone Stimulus
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Leukocyte telomere length ( 32109421)	Asthma ( 31959851)
Interacting Genes		5 interacting genes: ADIPOQ FNDC9 GJA8 IGFBP5 UBE2J1	88 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 AQP1 ASGR1 ATXN1 BMP10 C1QL4 C3orf52 CLDN1 CLDN11 CLDN19 CLEC1A CLEC2D CLEC7A CLN6 CLRN2 CMTM5 CNIH3 COL8A2 CTSA CXCL16 CXCL9 CYB5B DEFB132 DOLK EDDM3B EMP3 ENTPD3 ERMP1 EXTL1 GALNT15 GCNT2 HHATL IGFBP5 ITM2A ITM2C JAGN1 KRTCAP3 LHFPL5 LPAR3 MAL MALL MOSPD3 NINJ1 NINJ2 NKG7 NSG1 OLFM4 PGA4 PGAP2 PLLP PLN PLP1 PLP2 PLPP6 PROKR2 RPRM SEC22B SERP2 SFTPC SLC35A1 SLC41A2 SMIM1 SMIM3 ST6GAL2 STX8 TMEM100 TMEM140 TMEM182 TMEM254 TMEM60 TMEM79 TMEM86A TMPRSS4 TNF TRARG1 TREX1 TSPO2 TWSG1 UBIAD1 UPK1B UPK2 VAMP5 VSTM1 ZDHHC22 ZFPL1
Entrez ID		128674	408263
HPRD ID		08453	17524
Ensembl ID		ENSG00000101292	ENSG00000172568
Uniprot IDs		A8K1T0 Q8NFJ6	Q8TBE3
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Migration Cellular Response To CAMP Negative Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Intracellular Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Response To Purine-containing Compound Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Insulin-like Growth Factor Ternary Complex Negative Regulation Of Protein Autophosphorylation Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Regulation Of Cholesterol Import Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Response To Sucrose Response To Disaccharide Hrd1p Ubiquitin Ligase Complex Insulin-like Growth Factor II Binding Negative Regulation Of Macrophage Differentiation Adiponectin-activated Signaling Pathway Regulation Of Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Intercellular Transport Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Exit From Endoplasmic Reticulum	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Structural Constituent Of Myelin Sheath Plasma Membrane Protein Binding Positive Regulation Of Neutrophil Activation Golgi Apparatus Axon Ensheathment Cytokine Activity Membrane Destabilizing Activity Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein Localization To Cell Periphery
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