PTP4A2 and MPO

Number of citations: 81 (PubMedID 36300783)
Data Source: BioGRID (pull down)

		PTP4A2	MPO
Name		protein tyrosine phosphatase 4A2	myeloperoxidase
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Secretory Granule Azurophil Granule Lumen Azurophil Granule Extracellular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity	Chromatin Binding Peroxidase Activity Protein Binding Heparin Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process	None	Response To Yeast Hypochlorous Acid Biosynthetic Process Respiratory Burst Involved In Defense Response Defense Response Response To Oxidative Stress Response To Mechanical Stimulus Removal Of Superoxide Radicals Response To Food Response To Lipopolysaccharide Low-density Lipoprotein Particle Remodeling Defense Response To Bacterium Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Defense Response To Fungus Response To Gold Nanoparticle
Pathways		RAB geranylgeranylation	Neutrophil degranulation Events associated with phagocytolytic activity of PMN cells
Drugs		None	Cefdinir Levocarnitine Melatonin Nomifensine
Diseases		None	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 )	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels in cardiovascular risk ( 28369058 ) Circulating myeloperoxidase levels (plasma) ( 23620142 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 27863252 )
Novel Interactors		None recorded	1 novel interactors: IRS2
Interacting Genes		13 interacting genes: AKAP8L ATF7 CARS1 CNNM1 CNNM3 DHX15 DUSP22 EWSR1 HSP90AA1 HSP90AB1 MPO RABGGTB WIPF2	3 interacting genes: CEBPA CP PTP4A2
Entrez ID		8073	4353
HPRD ID		03348	06102
Ensembl ID		ENSG00000184007	ENSG00000005381
Uniprot IDs		Q12974	P05164
PDB IDs		5K22 5K23 5K25 6WUR	1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW 5MFA 5UZU 6AZP 6BMT 7OIH
GO Terms Enriched among Interactors		Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Magnesium Ion Homeostasis Axonal Growth Cone Chaperone-mediated Protein Complex Assembly RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Telomere Maintenance Via Telomerase Histone Deacetylase Binding Disordered Domain Specific Binding DNA Polymerase Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Protein Tyrosine Kinase Binding Tau Protein Binding CTP Binding DATP Binding Cellular Response To Heat Hypochlorous Acid Biosynthetic Process Protein Folding Chaperone Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cysteine-tRNA Ligase Activity Cysteinyl-tRNA Aminoacylation Double-stranded RNA Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Response To Gold Nanoparticle U2-type Post-mRNA Release Spliceosomal Complex Response To Alkaloid DNA Biosynthetic Process Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding Chromosome Organization Response To Heat Neuronal Cell Body Response To Transition Metal Nanoparticle Leading Edge Of Lamellipodium ATP Hydrolysis Activity Telomere Maintenance Melanosome Phagocytic Vesicle Lumen Rab-protein Geranylgeranyltransferase Complex	Carbohydrate Homeostasis CHOP-C/EBP Complex Glucose Homeostasis Lipid Homeostasis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chemical Homeostasis Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Phospholipid-hydroperoxide Glutathione Peroxidase Activity Ferroxidase Activity Oxidoreductase Activity, Acting On Metal Ions Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Protein Domain Specific Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Gland Development Homeostatic Process Phosphatidylinositol 3-kinase Activator Activity Fat Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Positive Regulation Of Fatty Acid Beta-oxidation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell Activation STAT Family Protein Binding Osteoblast Development Intracellular Copper Ion Homeostasis Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Type B Pancreatic Cell Proliferation