SLC12A4 and MB21D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC12A4	MB21D2
Description		solute carrier family 12 member 4	Mab-21 domain containing 2
Image
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding ATP Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Protein Serine/threonine Kinase Binding	Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein-containing Complex Binding Cadherin Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride Bumetanide
Diseases
GWAS		Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Anti-saccade response ( 29064472)
Interacting Genes		10 interacting genes: AP3M1 ATF7IP CNFN CYSRT1 KRTAP12-2 KRTAP19-2 MB21D2 MTNR1B TMEM102 ZNF655	13 interacting genes: ARHGEF5 ATXN7L2 BYSL CBX8 CIRSR DTNB EVI5 MORN3 RAB3IP REL SLC12A4 SPRY1 SPRY2
Entrez ID		6560	151963
HPRD ID		04987	14092
Ensembl ID		ENSG00000124067	ENSG00000180611
Uniprot IDs		B4DF30 Q9UP95	Q8IYB1
PDB IDs		6KKR 6KKT 6KKU 7AIP 7AIQ 7AIR 7TTH 7TTI	7LT1
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Axis Elongation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Ras Protein Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Import Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Lung Growth Ciliary Basal Body-plasma Membrane Docking Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development
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