CHORDC1 and TCAP

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		CHORDC1	TCAP
Description		cysteine and histidine rich domain containing 1	titin-cap
Image
GO Annotations	Cellular Component		Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex
	Molecular Function	Protein Binding ATP Binding Zinc Ion Binding ADP Binding Metal Ion Binding Hsp90 Protein Binding	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding
	Biological Process	Protein Folding Regulation Of Centrosome Duplication Centrosome Duplication Regulation Of Cellular Response To Heat	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways			Striated Muscle Contraction
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 27863252) White blood cell count (basophil) ( 27863252)	Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		7 interacting genes: HSP90AA1 HSP90AB1 NAP1L1 PAK1 PPP5C TCAP XPO1	38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN
Entrez ID		26973	8557
HPRD ID		05072	05133
Ensembl ID		ENSG00000110172	ENSG00000173991
Uniprot IDs		E9PPQ5 Q9UHD1	A2TDC0 O15273
PDB IDs		2YRT	1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Protein Folding Chaperone Complex Tau Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Protein-containing Complex TPR Domain Binding Telomerase Holoenzyme Complex Assembly Melanosome Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Skeletal Muscle Contraction ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process RNA Binding DNA Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Heat Protein Folding Chaperone Regulation Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Neuronal Cell Body Heat Shock Protein Binding Regulation Of Protein Catabolic Process CTP Binding DATP Binding Positive Regulation Of Protein Polymerization Striated Muscle Contraction Response To Unfolded Protein Response To Heat Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Alkaloid DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Cellular Response To Triglyceride Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein-containing Complex Assembly	Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process
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