CBLIF and SLC7A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBLIF	SLC7A1
Description		cobalamin binding intrinsic factor	solute carrier family 7 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Cobalamin Binding Molecular Carrier Activity Cargo Receptor Ligand Activity	L-ornithine Transmembrane Transporter Activity Virus Receptor Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Symbiont Entry Into Host Cell Transmembrane Transport Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane L-arginine Transmembrane Transport
Pathways		Defective CBLIF causes IFD Defective AMN causes MGA1 Defective CUBN causes MGA1 Uptake of dietary cobalamins into enterocytes	Amino acid transport across the plasma membrane
Drugs			Lysine Arginine Ornithine
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		8 interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237	56 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4
Entrez ID		2694	6541
HPRD ID		02024	00091
Ensembl ID		ENSG00000134812	ENSG00000139514
Uniprot IDs		P27352	P30825
PDB IDs		2PMV 3KQ4
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Activity Plasma Membrane Amino Acid Transmembrane Transporter Activity Symbiont Entry Into Host Cell Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Amino Acid Transport Lysine Transport L-ornithine Transmembrane Transport Amino Acid Transmembrane Transport Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-histidine Import Across Plasma Membrane Extrinsic Component Of External Side Of Plasma Membrane Sodium:sulfate Symporter Activity Import Into Cell Ubiquitin-dependent Endocytosis Biological Process Involved In Interaction With Host Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction L-lysine Transmembrane Transport Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-arginine Import Across Plasma Membrane Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Leukocyte Chemotaxis Involved In Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Cobalamin Transport Cobalamin Metabolic Process Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Aromatic Amino Acid Transport Cobalamin Binding L-arginine Transmembrane Transport	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Serotonin Secretion Zinc Ion Transmembrane Transporter Activity Chemical Homeostasis Zinc Ion Transport Zinc Ion Transmembrane Transport Plasma Membrane Monoatomic Cation Homeostasis Monoatomic Ion Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Organic Hydroxy Compound Transport Monoatomic Ion Homeostasis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Homeostasis Transmembrane Transport Inorganic Ion Transmembrane Transport Negative Regulation Of Growth Hormone Receptor Signaling Pathway Inorganic Ion Homeostasis Monoatomic Ion Transmembrane Transport Serotonin Transport Metal Ion Transport Regulation Of Growth Hormone Receptor Signaling Pathway Acetylcholine Receptor Binding Monoatomic Cation Transmembrane Transport Neuron Remodeling
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