GIF

Gene Name		gastric intrinsic factor (vitamin B synthesis)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen
	Molecular Function	Cobalamin Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalt Ion Transport Cobalamin Metabolic Process Cobalamin Transport Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: CBL CUBN
Entrez ID		2694
HPRD ID		02024
Ensembl ID		ENSG00000134812
Uniprot IDs		P27352
PDB IDs		2CKT 2PMV 3KQ4
Enriched GO Terms of Interacting Partners?		Cobalamin Transport Vitamin D Metabolic Process Cobalamin Metabolic Process Lipoprotein Transport Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vitamin Transport Negative Regulation Of ERBB Signaling Pathway
Tagcloud ?		balb exposed extremely filtration former fresh icr immune inactivated inoculated inoculation jcl kidney lks lymphokines mif monolayers multiplication multiplied penetration remarkably rupture sephadex spread tachyzoite tachyzoites totally toxo toxoplasma