CBLIF and CUBN

Number of citations of the paper that reports this interaction (PubMedID 9572993)
0

Data Source:
HPRD (in vitro)

		CBLIF	CUBN
Description		cobalamin binding intrinsic factor	cubilin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen	Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Brush Border Clathrin-coated Pit Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Cell Projection Membrane Brush Border Membrane Microvillus Membrane Lysosomal Lumen Receptor Complex Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protein Binding Cobalamin Binding Molecular Carrier Activity Cargo Receptor Ligand Activity	Calcium Ion Binding Protein Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport	Tissue Homeostasis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Protein Transport Cobalamin Transport Lipoprotein Transport Establishment Of Localization In Cell
Pathways		Defective CBLIF causes IFD Defective AMN causes MGA1 Defective CUBN causes MGA1 Uptake of dietary cobalamins into enterocytes	Vitamin D (calciferol) metabolism Defective AMN causes MGA1 Defective CUBN causes MGA1 HDL clearance Uptake of dietary cobalamins into enterocytes
Drugs			Hydroxocobalamin
Diseases
GWAS			Binge eating behaviour in bipolar disorder ( 29391396) Bipolar disorder (early vs late onset) ( 34016946) Cholesterol, total ( 24097068) Colorectal cancer ( 25990418) Folate pathway vitamin levels ( 19744961 19303062) High density lipoprotein cholesterol levels ( 30498476) Homocysteine levels ( 23824729) Metabolite levels ( 23823483) Microalbuminuria ( 26631737 31511532) Molybdenum levels ( 26025379) Platelet distribution width ( 27863252) Plateletcrit ( 32888494) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Quantitative traits ( 19197348) Superior temporal gyrus volume ( 31530798) Total cholesterol levels ( 28334899) Total grey matter volume ( 31530798) Urate levels ( 31578528) Urinary albumin excretion ( 30220432 21355061) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 30910378 27650483 31511532 26631737 31630189) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Vitamin B levels in ischemic stroke ( 25147783) Whole-brain volume ( 21116278)
Interacting Genes		8 interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237	9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF
Entrez ID		2694	8029
HPRD ID		02024	04296
Ensembl ID		ENSG00000134812	ENSG00000107611
Uniprot IDs		P27352	O60494
PDB IDs		2PMV 3KQ4	3KQ4 6GJE
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Activity Plasma Membrane Amino Acid Transmembrane Transporter Activity Symbiont Entry Into Host Cell Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Amino Acid Transport Lysine Transport L-ornithine Transmembrane Transport Amino Acid Transmembrane Transport Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-histidine Import Across Plasma Membrane Extrinsic Component Of External Side Of Plasma Membrane Sodium:sulfate Symporter Activity Import Into Cell Ubiquitin-dependent Endocytosis Biological Process Involved In Interaction With Host Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction L-lysine Transmembrane Transport Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-arginine Import Across Plasma Membrane Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Leukocyte Chemotaxis Involved In Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Cobalamin Transport Cobalamin Metabolic Process Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Aromatic Amino Acid Transport Cobalamin Binding L-arginine Transmembrane Transport	Vitamin Transport Cobalamin Transport Blood Microparticle Extracellular Space Vitamin D Metabolic Process Vitamin Transmembrane Transport Extracellular Region Extracellular Exosome Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Programmed Cell Death Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Process Protein Autoubiquitination BRCA1-BARD1 Complex Positive Regulation Of Receptor-mediated Endocytosis Response To Growth Factor Regulation Of Endocytosis Calcidiol Binding Lysosomal Lumen Apical Plasma Membrane Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Folate Import Across Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Clathrin-coated Pit Endocytic Vesicle Polychlorinated Biphenyl Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding SH3 Domain Binding Male Gonad Development Cargo Receptor Ligand Activity Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Folate Transmembrane Transport Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Response To Nutrient Levels Regulation Of Receptor-mediated Endocytosis Transmembrane Transport Response To Stress BRCA1-B Complex Regulation Of Rap Protein Signal Transduction Response To Ozone Response To Silicon Dioxide
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