CBLIF and SLC13A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBLIF	SLC13A4
Description		cobalamin binding intrinsic factor	solute carrier family 13 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen	Plasma Membrane Membrane
	Molecular Function	Protein Binding Cobalamin Binding Molecular Carrier Activity Cargo Receptor Ligand Activity	Protein Binding Symporter Activity Solute:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Sulfate Transmembrane Transport
Pathways		Defective CBLIF causes IFD Defective AMN causes MGA1 Defective CUBN causes MGA1 Uptake of dietary cobalamins into enterocytes	Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Diverticular disease ( 30177863)
Interacting Genes		8 interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237	26 interacting genes: ACKR2 CBLIF CD79A CDS1 CERS4 DEFB108B DERL3 EFNA5 EOGT ERMP1 FCER1G GJA5 GPR152 GPR61 IER3 IGFBP5 MS4A13 OPRD1 OTOP3 SLC35A4 SLC35E4 SLC38A1 SLC41A1 TMEM147 TMEM60 TRARG1
Entrez ID		2694	26266
HPRD ID		02024	10372
Ensembl ID		ENSG00000134812	ENSG00000164707
Uniprot IDs		P27352	A0A804HKQ4 Q59HF0 Q9UKG4
PDB IDs		2PMV 3KQ4
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Activity Plasma Membrane Amino Acid Transmembrane Transporter Activity Symbiont Entry Into Host Cell Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Amino Acid Transport Lysine Transport L-ornithine Transmembrane Transport Amino Acid Transmembrane Transport Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-histidine Import Across Plasma Membrane Extrinsic Component Of External Side Of Plasma Membrane Sodium:sulfate Symporter Activity Import Into Cell Ubiquitin-dependent Endocytosis Biological Process Involved In Interaction With Host Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction L-lysine Transmembrane Transport Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-arginine Import Across Plasma Membrane Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Leukocyte Chemotaxis Involved In Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Cobalamin Transport Cobalamin Metabolic Process Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Aromatic Amino Acid Transport Cobalamin Binding L-arginine Transmembrane Transport	Membrane
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