CBLIF and FFAR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBLIF	FFAR2
Description		cobalamin binding intrinsic factor	free fatty acid receptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen	Plasma Membrane Membrane Cell Projection
	Molecular Function	Protein Binding Cobalamin Binding Molecular Carrier Activity Cargo Receptor Ligand Activity	G Protein-coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport	Leukocyte Chemotaxis Involved In Inflammatory Response Immune System Process Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Insulin Secretion Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-8 Production Glucose Homeostasis Fat Cell Differentiation Negative Regulation Of Insulin Secretion Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Ligand-gated Ion Channel Signaling Pathway
Pathways		Defective CBLIF causes IFD Defective AMN causes MGA1 Defective CUBN causes MGA1 Uptake of dietary cobalamins into enterocytes	G alpha (q) signalling events Free fatty acid receptors
Drugs			GLPG-0974
Diseases
GWAS			Hemoglobin ( 32888494) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		8 interacting genes: CBL CUBN FFAR2 SLC13A4 SLC22A23 SLC7A1 SLC7A14 TMEM237	120 interacting genes: AGPAT4 AGTRAP ALOX5AP ANKRD46 APOD ARLN ATP13A1 ATP6V0C BMP10 BNIP3 BTN2A2 C11orf24 C3orf52 CACNG1 CATSPERH CBLIF CCDC167 CD82 CDIPT CFHR5 CGRRF1 CLDN4 CLDND2 CLEC1A CMTM5 CMTM7 CNIH1 COL4A5 CXCL16 CXCL9 CYB561A3 CYB5R2 DERL1 EDDM3B EMC6 EMP1 ERG28 FAM20B FAM3C FAXDC2 FCER1G FIS1 FXYD3 FXYD6 FZD7 GALNT15 GJB2 GNAO1 GNAQ GPR37L1 GUCA2A GYPA IFITM3 IGF1R IGFBP5 KRT1 KTN1 LAPTM4A LAT LEPROTL1 LHFPL5 LPAR3 MALL MS4A13 NAT8 NIPAL4 NKG7 NRM NSG1 NUCB2 OR10AG1 PEX16 PLP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SACM1L SCGB1D1 SELENOK SERP2 SLC30A2 SLC35B4 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A9 SLC41A1 SLC61A1 SMAGP SMCO4 SMIM1 STRIT1 STX8 SYNDIG1 TEX264 TM4SF4 TMEM11 TMEM120B TMEM128 TMEM144 TMEM147 TMEM203 TMEM218 TMEM229B TMEM239 TMEM243 TMEM60 TMEM86A TMEM86B TMEM97 TNF TSPO2 UNC50 UPK1B YIF1A YIPF2 YIPF6
Entrez ID		2694	2867
HPRD ID		02024	04824
Ensembl ID		ENSG00000134812	ENSG00000126262
Uniprot IDs		P27352	C6KYL4 O15552
PDB IDs		2PMV 3KQ4	8J22 8J23 8J24 8T3S 9K1D
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Activity Plasma Membrane Amino Acid Transmembrane Transporter Activity Symbiont Entry Into Host Cell Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Amino Acid Transport Lysine Transport L-ornithine Transmembrane Transport Amino Acid Transmembrane Transport Transmembrane Transport L-ornithine Transmembrane Transporter Activity L-histidine Import Across Plasma Membrane Extrinsic Component Of External Side Of Plasma Membrane Sodium:sulfate Symporter Activity Import Into Cell Ubiquitin-dependent Endocytosis Biological Process Involved In Interaction With Host Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction L-lysine Transmembrane Transport Ornithine Transport L-lysine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity L-histidine Transmembrane Transport L-arginine Import Across Plasma Membrane Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Leukocyte Chemotaxis Involved In Inflammatory Response Basic Amino Acid Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity Cobalamin Transport Cobalamin Metabolic Process Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment Aromatic Amino Acid Transport Cobalamin Binding L-arginine Transmembrane Transport	Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Bleb Assembly Alkenylglycerophosphocholine Hydrolase Activity Transmembrane Transport
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