TAB3 and MAP3K7CL

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		TAB3	MAP3K7CL
Gene Name		TGF-beta activated kinase 1/MAP3K7 binding protein 3	MAP3K7 C-terminal like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CEP57L1 IKBKG MAP3K7CL PIN1 TAB1 TRAF2 TRAF6 UBC	6 interactors: AK8 CISH GPS2 KRT31 REL TAB3
Entrez ID		257397	56911
HPRD ID		06738	10764
Ensembl ID		ENSG00000157625	ENSG00000156265
Uniprot IDs		Q8N5C8	B0EVZ6 B0EVZ8 P57077
PDB IDs
Enriched GO Terms of Interacting Partners?		I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MAPK Cascade Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity JNK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response Positive Regulation Of Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Modification Process Activation Of NF-kappaB-inducing Kinase Activity Activation Of MAPK Activity Positive Regulation Of MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Intracellular Receptor Signaling Pathway	I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase Activity MAPK Cascade Negative Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Signal Transduction Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Signaling Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of JNK Cascade Phosphorylation Inactivation Of MAPK Activity Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Nucleoside Diphosphate Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Interleukin-12 Production Ventricular System Development
Tagcloud ?		3p algorithms brdu coding confirming downregulated extracted gse54751 hcc hct hepatocellular hepg2 hypothesized ikk inverse luciferase micrornas mir mirnas mtt nearly p65 qrt rescued searching sixfold suitable tab2 targets
Tagcloud (Difference) ?		3p algorithms brdu coding confirming downregulated extracted gse54751 hcc hct hepatocellular hepg2 hypothesized ikk inverse luciferase micrornas mir mirnas mtt nearly p65 qrt rescued searching sixfold suitable tab2 targets
Tagcloud (Intersection) ?