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TAB3
Gene Name
TGF-beta activated kinase 1/MAP3K7 binding protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Biological Process
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TRAF6 mediated induction of TAK1 complex
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
FCERI mediated NF-kB activation
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
activated TAK1 mediates p38 MAPK activation
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
IRAK2 mediated activation of TAK1 complex
IRAK2 mediated activation of TAK1 complex
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-protein Interactions
8 interactors:
CEP57L1
IKBKG
MAP3K7CL
PIN1
TAB1
TRAF2
TRAF6
UBC
Entrez ID
257397
HPRD ID
06738
Ensembl ID
ENSG00000157625
Uniprot IDs
Q8N5C8
PDB IDs
Enriched GO Terms of Interacting Partners
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I-kappaB Kinase/NF-kappaB Signaling
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Positive Regulation Of Transferase Activity
Positive Regulation Of MAP Kinase Activity
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Innate Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of MAP Kinase Activity
JNK Cascade
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Innate Immune Response
Positive Regulation Of Phosphorylation
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Protein Modification Process
Activation Of NF-kappaB-inducing Kinase Activity
Activation Of MAPK Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Kinase Activity
Positive Regulation Of Cellular Protein Metabolic Process
NIK/NF-kappaB Signaling
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Cytokine Production
Positive Regulation Of Protein Metabolic Process
Intracellular Receptor Signaling Pathway
Tagcloud
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3p
algorithms
brdu
coding
confirming
downregulated
extracted
gse54751
hcc
hct
hepatocellular
hepg2
hypothesized
ikk
inverse
luciferase
micrornas
mir
mirnas
mtt
nearly
p65
qrt
rescued
searching
sixfold
suitable
tab2
targets