TAB3

Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Canonical NF-kappaB Signal Transduction Response To Bacterium Negative Regulation Of Autophagy Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: AMFR CEP57L1 IKBKG MAP3K7CL OGT PIN1 PPIL3 STAT3 TAB1 TRAF2 TRAF6 UBC
Entrez ID		257397
HPRD ID		06738
Ensembl ID		ENSG00000157625
Uniprot IDs		Q8N5C8
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Signaling Adaptor Activity Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process CD40 Receptor Complex Positive Regulation Of Signal Transduction Positive Regulation Of JUN Kinase Activity Ubiquitin Ligase Complex Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Gene Expression Negative Regulation Of Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Synapse Negative Regulation Of Signal Transduction Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Tumor Necrosis Factor Receptor Binding Regulation Of Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of MAP Kinase Activity Cytosol Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Protein Modification Process Protein-macromolecule Adaptor Activity Glutamatergic Synapse Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation
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