CYP2E1 and RPL13A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYP2E1	RPL13A
Gene Name		cytochrome P450, family 2, subfamily E, polypeptide 1	ribosomal protein L13a
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytosol Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex GAIT Complex
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding	Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Response To Ethanol Heterocycle Metabolic Process Oxidation-reduction Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Negative Regulation Of Translation Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Cellular Response To Interferon-gamma Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Hematological and biochemical traits ( 20139978)
Protein-Protein Interactions		15 interactors: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	13 interactors: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBXO18 FNTA GOLM1 ND1 RPL30 STOM VTN
Entrez ID		1571	23521
HPRD ID		11813	11775
Ensembl ID		ENSG00000130649	ENSG00000142541
Uniprot IDs		P05181	P40429 Q8J015
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z	3J3B
Enriched GO Terms of Interacting Partners?		Response To Misfolded Protein Reverse Cholesterol Transport Regulation Of Hormone Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Catabolic Process Organic Acid Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Organofluorine Metabolic Process L-alanine Catabolic Process, By Transamination Negative Regulation Of Formation Of Translation Preinitiation Complex Nitrate Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Nitric Oxide Catabolic Process Regulation Of Neuronal Signal Transduction Sterol Transport Cholesterol Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Fatty Acid Oxidation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Lipid Oxidation Positive Regulation Of Proteasomal Protein Catabolic Process Creatine Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of Neurofibrillary Tangle Assembly Glycine Biosynthetic Process, By Transamination Of Glyoxylate Positive Regulation Of Reactive Oxygen Species Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Steroid Metabolic Process Cellular Response To Unfolded Protein Glyoxylate Catabolic Process Nitrate Metabolic Process Glial Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stimulus L-alanine Metabolic Process L-alanine Catabolic Process Central Nervous System Myelin Maintenance Single-organism Behavior Response To Organic Substance Regulation Of Tau-protein Kinase Activity Response To Unfolded Protein Cellular Amino Acid Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Rhodopsin Mediated Signaling Pathway Response To Inorganic Substance Rhodopsin Mediated Signaling Pathway Positive Regulation Of Tubulin Deacetylation Regulation Of Acid-sensing Ion Channel Activity Regulation Of Cation Channel Activity Phototransduction, Visible Light Detection Of Visible Light Positive Regulation Of Protein Modification Process Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Cellular Metabolic Process Detection Of Light Stimulus Catabolic Process Response To Calcium Ion Nucleus Organization Response To Intra-S DNA Damage Checkpoint Signaling Protein Farnesylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Radiation Response To Ethanol Regulation Of Tubulin Deacetylation PML Body Organization Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Xenobiotic Stimulus Positive Regulation Of Deacetylase Activity Monoterpenoid Metabolic Process Response To Ozone Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Protein Metabolic Process Synaptic Transmission Wound Healing Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Immune Response Regulation Of Immune System Process Negative Regulation Of Vasodilation Neurotransmitter Receptor Metabolic Process Protein Geranylgeranylation Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ethanol Catabolic Process Response To Reactive Oxygen Species Positive Regulation Of Superoxide Anion Generation
Tagcloud ?		afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified	aleyrodidae bemisia bestkeeper cyclophilin cyp1 developmentally ef1a gapdh gennadius genorm glyceraldehyde hemiptera normalisation normfinder orthologs qpcr realtime selecting sented suitability tabaci thermal transcript tub1a utilising vitellogenin whiteflies whitefly
Tagcloud (Difference) ?		afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified	aleyrodidae bemisia bestkeeper cyclophilin cyp1 developmentally ef1a gapdh gennadius genorm glyceraldehyde hemiptera normalisation normfinder orthologs qpcr realtime selecting sented suitability tabaci thermal transcript tub1a utilising vitellogenin whiteflies whitefly
Tagcloud (Intersection) ?