CYP2E1 and RPL13A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYP2E1	RPL13A
Description		cytochrome P450 family 2 subfamily E member 1	ribosomal protein L13a
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Metal Ion Binding Hsp90 Protein Binding Long-chain Fatty Acid Omega-1 Hydroxylase Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process	Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Translation Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Homeostatic Process Macrophage Chemotaxis Lung Morphogenesis Cellular Response To Type II Interferon Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME Paracetamol ADME	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Diacerein	(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Hematological and biochemical traits ( 20139978) Monocyte count ( 32888494)
Interacting Genes		15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	15 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FILNC1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN
Entrez ID		1571	23521
HPRD ID		11813	11775
Ensembl ID		ENSG00000130649	ENSG00000142541
Uniprot IDs		P05181	A0A384ME37 P40429 Q8J015
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Ubiquitin-ubiquitin Ligase Activity Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Intracellular Membrane-bounded Organelle Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Tau Protein Binding Regulation Of Neuronal Signal Transduction Monocarboxylic Acid Metabolic Process 3-hydroxypropionyl-CoA Dehydratase Activity Modified Amino Acid Metabolic Process Glycine Amidinotransferase Activity Amidinotransferase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Regulation Of Hormone Metabolic Process Nitrate Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Formation Of Translation Preinitiation Complex Beta-alanine:pyruvate Transaminase Activity N(omega),N(omega)-dimethyl-L-arginine Catabolic Process (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity L-alanine Catabolic Process, By Transamination Regulation Of Cellular Response To Stress Protein Polyubiquitination Endoplasmic Reticulum Learning Or Memory Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Regulation Of Multicellular Organismal Process Cholesterol Transport Mitochondrion Macrophage Activation Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Crotonyl-CoA Hydratase Activity Creatine Biosynthetic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Dendrite Regeneration Positive Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cytoplasmic Translational Initiation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Regulation Of Cell Population Proliferation Cognition
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