CYP2E1 and AGXT2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CYP2E1	AGXT2
Description		cytochrome P450 family 2 subfamily E member 1	alanine--glyoxylate aminotransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen 4-nitrophenol 2-monooxygenase Activity Oxygen Binding Enzyme Binding Heme Binding Hsp70 Protein Binding Metal Ion Binding Hsp90 Protein Binding Long-chain Fatty Acid Omega-1 Hydroxylase Activity	Alanine-glyoxylate Transaminase Activity Transaminase Activity Beta-alanine:pyruvate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Hydroxylation Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Bacterium Monoterpenoid Metabolic Process Carbon Tetrachloride Metabolic Process Benzene Metabolic Process 4-nitrophenol Metabolic Process Epoxygenase P450 Pathway Halogenated Hydrocarbon Metabolic Process Long-chain Fatty Acid Biosynthetic Process	Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Positive Regulation Of Nitric Oxide Biosynthetic Process N(omega),N(omega)-dimethyl-L-arginine Catabolic Process
Pathways		Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME Paracetamol ADME	Glyoxylate metabolism and glycine degradation Pyrimidine catabolism
Drugs		Diacerein	Pyridoxal phosphate Pyruvic acid Glycine Alanine
Diseases
GWAS		Childhood body mass index ( 31752434) Coffee consumption ( 31046077) Gout ( 22179738) Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Metabolite levels ( 21931564) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748) Symmetrical dimethylarginine levels ( 24159190 25245031) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites ( 21572414 26352407) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		15 interacting genes: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	2 interacting genes: ALDOB CYP2E1
Entrez ID		1571	64902
HPRD ID		11813	10638
Ensembl ID		ENSG00000130649	ENSG00000113492
Uniprot IDs		P05181	Q9BYV1
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Ubiquitin-ubiquitin Ligase Activity Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Intracellular Membrane-bounded Organelle Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Tau Protein Binding Regulation Of Neuronal Signal Transduction Monocarboxylic Acid Metabolic Process 3-hydroxypropionyl-CoA Dehydratase Activity Modified Amino Acid Metabolic Process Glycine Amidinotransferase Activity Amidinotransferase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Regulation Of Hormone Metabolic Process Nitrate Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Formation Of Translation Preinitiation Complex Beta-alanine:pyruvate Transaminase Activity N(omega),N(omega)-dimethyl-L-arginine Catabolic Process (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity L-alanine Catabolic Process, By Transamination Regulation Of Cellular Response To Stress Protein Polyubiquitination Endoplasmic Reticulum Learning Or Memory Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Regulation Of Multicellular Organismal Process Cholesterol Transport Mitochondrion Macrophage Activation Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Crotonyl-CoA Hydratase Activity Creatine Biosynthetic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Dendrite Regeneration Positive Regulation Of Reverse Cholesterol Transport Negative Regulation Of Cytoplasmic Translational Initiation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Regulation Of Cell Population Proliferation Cognition	Fructose-1-phosphate Aldolase Activity Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Fructose-bisphosphate Aldolase Activity Negative Regulation Of Pentose-phosphate Shunt Small Molecule Biosynthetic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly Monocarboxylic Acid Metabolic Process Regulation Of Pentose-phosphate Shunt Lipid Hydroxylation Long-chain Fatty Acid Omega-1 Hydroxylase Activity Monoterpenoid Metabolic Process Fructose Binding Proton-transporting V-type ATPase Complex Assembly Regulation Of NADP Metabolic Process Fructose 1,6-bisphosphate Metabolic Process Arachidonate Epoxygenase Activity Glyceraldehyde-3-phosphate Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Fructose Metabolic Process Epoxygenase P450 Pathway Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Benzene-containing Compound Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Long-chain Fatty Acid Biosynthetic Process ADP Catabolic Process Gluconeogenesis ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Hexose Biosynthetic Process Small Molecule Metabolic Process Ribonucleoside Diphosphate Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Hsp90 Protein Binding Hsp70 Protein Binding Arachidonate Metabolic Process Pyruvate Metabolic Process Cytoskeletal Protein Binding Regulation Of Carbohydrate Catabolic Process Aldehyde Metabolic Process Monooxygenase Activity
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