CYP2E1 and AGXT2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYP2E1	AGXT2
Gene Name		cytochrome P450, family 2, subfamily E, polypeptide 1	alanine--glyoxylate aminotransferase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding	Alanine-glyoxylate Transaminase Activity Beta-alanine-pyruvate Transaminase Activity Pyridoxal Phosphate Binding (R)-3-amino-2-methylpropionate-pyruvate Transaminase Activity
	Biological Process	Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Response To Ethanol Heterocycle Metabolic Process Oxidation-reduction Process	Pyrimidine Nucleobase Metabolic Process Glyoxylate Catabolic Process Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-alanine Catabolic Process, By Transamination Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Glyoxylate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Pyrimidine catabolism Glyoxylate metabolism Pyrimidine metabolism Metabolism of nucleotides Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate Pyruvic acid Glycine L-Alanine
Diseases
GWAS		Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Metabolite levels ( 21931564) Urinary metabolites ( 21572414)
Protein-Protein Interactions		15 interactors: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1	2 interactors: ALDOB CYP2E1
Entrez ID		1571	64902
HPRD ID		11813	10638
Ensembl ID		ENSG00000130649	ENSG00000113492
Uniprot IDs		P05181	E9PDL7 Q9BYV1
PDB IDs		3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Response To Misfolded Protein Reverse Cholesterol Transport Regulation Of Hormone Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Catabolic Process Organic Acid Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Organofluorine Metabolic Process L-alanine Catabolic Process, By Transamination Negative Regulation Of Formation Of Translation Preinitiation Complex Nitrate Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Nitric Oxide Catabolic Process Regulation Of Neuronal Signal Transduction Sterol Transport Cholesterol Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Fatty Acid Oxidation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Lipid Oxidation Positive Regulation Of Proteasomal Protein Catabolic Process Creatine Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of Neurofibrillary Tangle Assembly Glycine Biosynthetic Process, By Transamination Of Glyoxylate Positive Regulation Of Reactive Oxygen Species Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Steroid Metabolic Process Cellular Response To Unfolded Protein Glyoxylate Catabolic Process Nitrate Metabolic Process Glial Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stimulus L-alanine Metabolic Process L-alanine Catabolic Process Central Nervous System Myelin Maintenance Single-organism Behavior Response To Organic Substance Regulation Of Tau-protein Kinase Activity Response To Unfolded Protein Cellular Amino Acid Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Fructose Catabolic Process Fructose 1,6-bisphosphate Metabolic Process Monoterpenoid Metabolic Process Vacuolar Proton-transporting V-type ATPase Complex Assembly NADH Oxidation Response To Ozone Monocarboxylic Acid Metabolic Process NADH Metabolic Process Epoxygenase P450 Pathway Fructose Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Positive Regulation Of ATPase Activity Drug Metabolic Process Regulation Of ATPase Activity Oxidation-reduction Process NAD Metabolic Process Gluconeogenesis Arachidonic Acid Metabolic Process Hexose Biosynthetic Process Catabolic Process Nicotinamide Nucleotide Metabolic Process Triglyceride Metabolic Process Glycolytic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Pyruvate Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Ethanol Glucose Metabolic Process Response To Xenobiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Response To Reactive Oxygen Species Pathogenesis Hexose Metabolic Process Monosaccharide Metabolic Process Steroid Metabolic Process Fatty Acid Metabolic Process
Tagcloud ?		afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Difference) ?		afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Intersection) ?